Activation of Skeletal Stem and Progenitor Cells for Bone Regeneration Is Driven by PDGFRβ Signaling

Anna Marei Böhm, Naomi Dirckx, Robert J. Tower, Nicolas Peredo, Sebastiaan Vanuytven, Koen Theunis, Elena Nefyodova, Ruben Cardoen, Volkhard Lindner, Thierry Voet, Matthias Van Hul, Christa Maes

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Böhm et al. show that bone injury activates multiple Osx+-marked cell subsets in the bone and bone marrow environment, representing osteogenesis-competent skeletal stem and progenitor cells (SSPCs). These include PDGFRβ+ SSPCs residing in perivascular niches. The authors found that PDGF-PDGFRβ signaling is functionally required to drive the expansion, recruitment, and blood vessel affinity of reparative SSPCs.

Original languageEnglish (US)
Pages (from-to)236-254.e12
JournalDevelopmental cell
Volume51
Issue number2
DOIs
StatePublished - Oct 21 2019
Externally publishedYes

Keywords

  • PDGF
  • PDGF receptor
  • blood vessels
  • bone
  • bone marrow stromal cells
  • bone regeneration
  • fracture repair
  • osteoprogenitors
  • pericytes
  • skeletal stem cells

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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