Activation of the myogenic lineage by MEF2A, a factor that induces and cooperates with MyoD

Sunjay Kaushal, Jay W. Schneider, Bernardo Nadal-Ginard, Vijak Mahdavi

Research output: Contribution to journalArticle

189 Scopus citations

Abstract

Muscle enhancer factor-2A (MEF2A), a member of the MADS family, induced myogenic development when ectopically expressed in clones of nonmuscle cells of human clones a function previously limited to the muscle basic helix-loop-helix (bHLH) proteins. During myogenesis, ME2A and bHLH proteins cooperatively activate skeletal muscle genes and physically interact through the MADS domain of MEF2A and the three myogenic amino-acids of the muscle bHLH proteins. Thus, skeletal myogenesis is mediated by two distinct families of mutually inducible and interactive muscle transcription factors, either of which can initiate the developmental cascade.

Original languageEnglish (US)
Pages (from-to)1236-1240
Number of pages5
JournalScience
Volume266
Issue number5188
DOIs
StatePublished - Jan 1 1994

ASJC Scopus subject areas

  • General

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    Kaushal, S., Schneider, J. W., Nadal-Ginard, B., & Mahdavi, V. (1994). Activation of the myogenic lineage by MEF2A, a factor that induces and cooperates with MyoD. Science, 266(5188), 1236-1240. https://doi.org/10.1126/science.7973707