TY - JOUR
T1 - Activation of the myogenic lineage by MEF2A, a factor that induces and cooperates with MyoD
AU - Kaushal, Sunjay
AU - Schneider, Jay W.
AU - Nadal-Ginard, Bernardo
AU - Mahdavi, Vijak
PY - 1994
Y1 - 1994
N2 - Muscle enhancer factor-2A (MEF2A), a member of the MADS family, induced myogenic development when ectopically expressed in clones of nonmuscle cells of human clones a function previously limited to the muscle basic helix-loop-helix (bHLH) proteins. During myogenesis, ME2A and bHLH proteins cooperatively activate skeletal muscle genes and physically interact through the MADS domain of MEF2A and the three myogenic amino-acids of the muscle bHLH proteins. Thus, skeletal myogenesis is mediated by two distinct families of mutually inducible and interactive muscle transcription factors, either of which can initiate the developmental cascade.
AB - Muscle enhancer factor-2A (MEF2A), a member of the MADS family, induced myogenic development when ectopically expressed in clones of nonmuscle cells of human clones a function previously limited to the muscle basic helix-loop-helix (bHLH) proteins. During myogenesis, ME2A and bHLH proteins cooperatively activate skeletal muscle genes and physically interact through the MADS domain of MEF2A and the three myogenic amino-acids of the muscle bHLH proteins. Thus, skeletal myogenesis is mediated by two distinct families of mutually inducible and interactive muscle transcription factors, either of which can initiate the developmental cascade.
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U2 - 10.1126/science.7973707
DO - 10.1126/science.7973707
M3 - Article
C2 - 7973707
AN - SCOPUS:0028047014
SN - 0036-8075
VL - 266
SP - 1236
EP - 1240
JO - Science
JF - Science
IS - 5188
ER -