Active MHC class Ib genes in rat are pseudogenes in the mouse

Doris Lambracht-Washington; Kirsten Fischer Lindahl

doi:10.1007/s00251-004-0671-4

Active MHC class Ib genes in rat are pseudogenes in the mouse

Doris Lambracht-Washington, Kirsten Fischer Lindahl

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The most telomeric class I region of the MHC in rat and mouse is the M region, which contains about 20 class I genes or gene fragments. The central part carries three class I genes - M4, M5, and M6 - which are orthologous between the two species. M4 and M6 are pseudogenes in the mouse but transcribed, intact genes in the rat. To analyze the pseudogene status for the mouse genes in more detail, we have sequenced the respective exons in multiple representative haplotypes. The stop codons are conserved in all mouse strains analyzed, and, consistent with the pseudogene status, all strains show additional insertions and deletions, taking the genes further away from functionality. Thus, M4 and M6 indeed have a split status. They are silent in the mouse but intact in the closely related rodent, the rat.

Original language	English (US)
Pages (from-to)	118-121
Number of pages	4
Journal	Immunogenetics
Volume	56
Issue number	2
DOIs	https://doi.org/10.1007/s00251-004-0671-4
State	Published - May 2004

Keywords

H2-M region
Interspecies comparison
Orthologous genes
Pseudogenes
RT1.M region

ASJC Scopus subject areas

Immunology
Genetics

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10.1007/s00251-004-0671-4

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title = "Active MHC class Ib genes in rat are pseudogenes in the mouse",

abstract = "The most telomeric class I region of the MHC in rat and mouse is the M region, which contains about 20 class I genes or gene fragments. The central part carries three class I genes - M4, M5, and M6 - which are orthologous between the two species. M4 and M6 are pseudogenes in the mouse but transcribed, intact genes in the rat. To analyze the pseudogene status for the mouse genes in more detail, we have sequenced the respective exons in multiple representative haplotypes. The stop codons are conserved in all mouse strains analyzed, and, consistent with the pseudogene status, all strains show additional insertions and deletions, taking the genes further away from functionality. Thus, M4 and M6 indeed have a split status. They are silent in the mouse but intact in the closely related rodent, the rat.",

keywords = "H2-M region, Interspecies comparison, Orthologous genes, Pseudogenes, RT1.M region",

author = "Doris Lambracht-Washington and Lindahl, {Kirsten Fischer}",

note = "Funding Information: Acknowledgement This work was supported in part by NIH grant AI 37818.",

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T1 - Active MHC class Ib genes in rat are pseudogenes in the mouse

AU - Lambracht-Washington, Doris

AU - Lindahl, Kirsten Fischer

N1 - Funding Information: Acknowledgement This work was supported in part by NIH grant AI 37818.

PY - 2004/5

Y1 - 2004/5

N2 - The most telomeric class I region of the MHC in rat and mouse is the M region, which contains about 20 class I genes or gene fragments. The central part carries three class I genes - M4, M5, and M6 - which are orthologous between the two species. M4 and M6 are pseudogenes in the mouse but transcribed, intact genes in the rat. To analyze the pseudogene status for the mouse genes in more detail, we have sequenced the respective exons in multiple representative haplotypes. The stop codons are conserved in all mouse strains analyzed, and, consistent with the pseudogene status, all strains show additional insertions and deletions, taking the genes further away from functionality. Thus, M4 and M6 indeed have a split status. They are silent in the mouse but intact in the closely related rodent, the rat.

AB - The most telomeric class I region of the MHC in rat and mouse is the M region, which contains about 20 class I genes or gene fragments. The central part carries three class I genes - M4, M5, and M6 - which are orthologous between the two species. M4 and M6 are pseudogenes in the mouse but transcribed, intact genes in the rat. To analyze the pseudogene status for the mouse genes in more detail, we have sequenced the respective exons in multiple representative haplotypes. The stop codons are conserved in all mouse strains analyzed, and, consistent with the pseudogene status, all strains show additional insertions and deletions, taking the genes further away from functionality. Thus, M4 and M6 indeed have a split status. They are silent in the mouse but intact in the closely related rodent, the rat.

KW - H2-M region

KW - Interspecies comparison

KW - Orthologous genes

KW - Pseudogenes

KW - RT1.M region

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Active MHC class Ib genes in rat are pseudogenes in the mouse

Abstract

Keywords

ASJC Scopus subject areas

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