@article{072344c9d93b49978ae294562250aee6,
title = "Activity-dependent regulation of inhibitory synapse development by Npas4",
abstract = "Neuronal activity regulates the development and maturation of excitatory and inhibitory synapses in the mammalian brain. Several recent studies have identified signalling networks within neurons that control excitatory synapse development. However, less is known about the molecular mechanisms that regulate the activity-dependent development of GABA (γ-aminobutyric acid)-releasing inhibitory synapses. Here we report the identification of a transcription factor, Npas4, that plays a role in the development of inhibitory synapses by regulating the expression of activity-dependent genes, which in turn control the number of GABA-releasing synapses that form on excitatory neurons. These findings demonstrate that the activity-dependent gene program regulates inhibitory synapse development, and suggest a new role for this program in controlling the homeostatic balance between synaptic excitation and inhibition.",
author = "Yingxi Lin and Bloodgood, {Brenda L.} and Hauser, {Jessica L.} and Lapan, {Ariya D.} and Koon, {Alex C.} and Kim, {Tae Kyung} and Hu, {Linda S.} and Malik, {Athar N.} and Greenberg, {Michael E.}",
note = "Funding Information: Acknowledgements We thank members of the Greenberg laboratory for suggestions; S. Paradis, J. M. Gray, S. S. Margolis, J. Zieg and C. M. Fletcher for reading the manuscript; S. Vasquez for preparing primary neuronal cell cultures; M. Thompson, Y. Zhou and H. Ye for assistance in generating Npas42/2 mice; T. Diefenbach and the Neurobiology Program Imaging Center for assistance with confocal microscopy; M. Fagiolini for help with dissection of the visual cortex; and X. J. Liu and C. Chen for help with electrophysiology. M.E.G. acknowledges the generous support of the F. M. Kirby Foundation to the Neurobiology Program of the Children{\textquoteright}s Hospital and support from the Nancy Lurie Marks Family Foundation. This work was supported by a Lefler Foundation postdoctoral fellowship (Y.L.), a Ruth L. Kirschstein National Research Service Award and a Helen Hay Whitney postdoctoral fellowship (B.L.B.), a National Science Foundation Graduate Research Fellowship (A.D.L.), the Jane Coffin Childs Memorial Fund (T.-K.K.) and Mental Retardation Research Center grant HD18655 and National Institutes of Health grants NS27572 and NS48276 (M.E.G.).",
year = "2008",
month = oct,
day = "30",
doi = "10.1038/nature07319",
language = "English (US)",
volume = "455",
pages = "1198--1204",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "7217",
}