Activity-inducible protein Homer1a/Vesl-1S promotes redistribution of postsynaptic protein Homer1c/Vesl-1L in cultured rat hippocampal neurons

Yuriko Inoue, Naoki Honkura, Akihiko Kato, Suchie Ogawa, Hiroshi Udo, Kaoru Inokuchi, Hiroyuki Sugiyama

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

In cultured rat hippocampal neurons, overexpression of Homer1a/Vesl-1S, an inducible protein upregulated by seizure or long-term potentiation, caused a reduction of punctate distribution of a postsynaptic protein Homer1c/Vesl-1L, without significant decrease in its total amount. Clusters of F-actin were also decreased. Treatments of cells with BDNF or a proteasome inhibitor, which cause increase in the expression level of endogenous Homer1a, also resulted in the reduction of Homer1c puncta. These results indicate that the accumulation of Homer1a, either exogenously expressed or endogenously induced, caused redistribution and dispersion of postsynaptic clusters of Homer1c and F-actin, suggesting an important role of Homer1a in synaptic remodeling.

Original languageEnglish (US)
Pages (from-to)143-147
Number of pages5
JournalNeuroscience Letters
Volume354
Issue number2
DOIs
Publication statusPublished - Jan 9 2004

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Keywords

  • Brain derived neurotrophic factor
  • F-actin
  • Homer
  • Long-term potentiation
  • Vesl

ASJC Scopus subject areas

  • Neuroscience(all)

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