TY - JOUR
T1 - Activity-inducible protein Homer1a/Vesl-1S promotes redistribution of postsynaptic protein Homer1c/Vesl-1L in cultured rat hippocampal neurons
AU - Inoue, Yuriko
AU - Honkura, Naoki
AU - Kato, Akihiko
AU - Ogawa, Suchie
AU - Udo, Hiroshi
AU - Inokuchi, Kaoru
AU - Sugiyama, Hiroyuki
N1 - Funding Information:
This work was supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture, Japan.
PY - 2004/1/9
Y1 - 2004/1/9
N2 - In cultured rat hippocampal neurons, overexpression of Homer1a/Vesl-1S, an inducible protein upregulated by seizure or long-term potentiation, caused a reduction of punctate distribution of a postsynaptic protein Homer1c/Vesl-1L, without significant decrease in its total amount. Clusters of F-actin were also decreased. Treatments of cells with BDNF or a proteasome inhibitor, which cause increase in the expression level of endogenous Homer1a, also resulted in the reduction of Homer1c puncta. These results indicate that the accumulation of Homer1a, either exogenously expressed or endogenously induced, caused redistribution and dispersion of postsynaptic clusters of Homer1c and F-actin, suggesting an important role of Homer1a in synaptic remodeling.
AB - In cultured rat hippocampal neurons, overexpression of Homer1a/Vesl-1S, an inducible protein upregulated by seizure or long-term potentiation, caused a reduction of punctate distribution of a postsynaptic protein Homer1c/Vesl-1L, without significant decrease in its total amount. Clusters of F-actin were also decreased. Treatments of cells with BDNF or a proteasome inhibitor, which cause increase in the expression level of endogenous Homer1a, also resulted in the reduction of Homer1c puncta. These results indicate that the accumulation of Homer1a, either exogenously expressed or endogenously induced, caused redistribution and dispersion of postsynaptic clusters of Homer1c and F-actin, suggesting an important role of Homer1a in synaptic remodeling.
KW - Brain derived neurotrophic factor
KW - F-actin
KW - Homer
KW - Long-term potentiation
KW - Vesl
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U2 - 10.1016/j.neulet.2003.09.082
DO - 10.1016/j.neulet.2003.09.082
M3 - Article
C2 - 14698459
AN - SCOPUS:0348048791
SN - 0304-3940
VL - 354
SP - 143
EP - 147
JO - Neuroscience letters
JF - Neuroscience letters
IS - 2
ER -