Acute anemia elicits cognitive dysfunction and evidence of cerebral cellular hypoxia in older rats with systemic hypertension

Min Li, Jessica A. Bertout, Sarah J. Ratcliffe, Maryellen F. Eckenhoff, M. Celeste Simon, Thomas F. Floyd

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background: Postoperative cognitive dysfunction occurs frequently after cardiac, major vascular, and major orthopedic surgery. Aging and hypertensive cerebrovascular disease are leading risk factors for this disorder. Acute anemia, common to major surgery, has been identified as a possible contributor to postoperative cognitive dysfunction. The effect of hypoxia upon cognition and the cellular and molecular processes involved in learning and memory has been well described. Cerebrovascular changes related to chronic hypertension may expose cells to increased hypoxia with anemia. Methods: Young to aged spontaneously hypertensive rats underwent testing for visuospatial memory and learning in the Morris water maze, measurement of cerebral tissue oxygenation via tissue oxygen probe, and measurement of hypoxia- sensitive genes and proteins, under conditions of sham and experimental isovolemic anemia. Results: Acute isovolemic anemia elicited evidence of agingdependent visuospatial working memory and learning impairment. Isovolemic anemia did not result in cerebral tissue hypoxia, when measured via tissue oxygen probe. Evidence of cellular hypoxia was, however, identified in response to the anemic challenge, as hypoxia-sensitive genes and proteins were up-regulated. Importantly, cellular hypoxic gene responses were increased with anemia in an age-dependent manner in this model of aging with chronic hypertension. Conclusions: In a translational model of chronic hypertension, clinically relevant levels of acute anemia were associated with an age-dependent visuospatial working memory and learning impairment that was matched by an age-dependent cellular sensitivity to anemic hypoxia. These data offer support for a possible link between anemic hypoxia and postoperative cognitive dysfunction in humans.

Original languageEnglish (US)
Pages (from-to)845-858
Number of pages14
JournalAnesthesiology
Volume113
Issue number4
DOIs
StatePublished - Jan 1 2010

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Cell Hypoxia
Brain Hypoxia
Anemia
Hypertension
Learning
Short-Term Memory
Oxygen
Cerebrovascular Disorders
Inbred SHR Rats
Cognitive Dysfunction
Cognition
Orthopedics
Blood Vessels
Hypoxia
Proteins
Water
Genes

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Acute anemia elicits cognitive dysfunction and evidence of cerebral cellular hypoxia in older rats with systemic hypertension. / Li, Min; Bertout, Jessica A.; Ratcliffe, Sarah J.; Eckenhoff, Maryellen F.; Simon, M. Celeste; Floyd, Thomas F.

In: Anesthesiology, Vol. 113, No. 4, 01.01.2010, p. 845-858.

Research output: Contribution to journalArticle

Li, Min ; Bertout, Jessica A. ; Ratcliffe, Sarah J. ; Eckenhoff, Maryellen F. ; Simon, M. Celeste ; Floyd, Thomas F. / Acute anemia elicits cognitive dysfunction and evidence of cerebral cellular hypoxia in older rats with systemic hypertension. In: Anesthesiology. 2010 ; Vol. 113, No. 4. pp. 845-858.
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