TY - JOUR
T1 - Acute antibody-mediated rejection in pediatric kidney transplants
T2 - A single center experience
AU - Twombley, Katherine
AU - Thach, Lonnie
AU - Ribeiro, Annelise
AU - Joseph, Catherine
AU - Seikaly, Mouin
PY - 2013/11
Y1 - 2013/11
N2 - aAMR is a potentially devastating complication of kidney transplantation. The incidence of aAMR in children, while thought to be rare, is not well defined, and there is a paucity of data on treatment regimens in children. We retrospectively reviewed the outcomes of our pediatric patients that were treated for aAMR between 2007 and 2009. Three adolescent Hispanic males were found to have aAMR. All three received deceased donor transplants, and all three verbalized non-adherence. Treatment consisted of rituximab, solumedrol, PE, and IVIgG in one patient, and PE, IVIgG, and bortezomib in two patients. The only side effect of therapy noted was mild hypotension with rituximab that resolved after decreasing the infusion rate. There were no reported infections two yr after treatment, and all of the viral monitoring in these patients remained negative.
AB - aAMR is a potentially devastating complication of kidney transplantation. The incidence of aAMR in children, while thought to be rare, is not well defined, and there is a paucity of data on treatment regimens in children. We retrospectively reviewed the outcomes of our pediatric patients that were treated for aAMR between 2007 and 2009. Three adolescent Hispanic males were found to have aAMR. All three received deceased donor transplants, and all three verbalized non-adherence. Treatment consisted of rituximab, solumedrol, PE, and IVIgG in one patient, and PE, IVIgG, and bortezomib in two patients. The only side effect of therapy noted was mild hypotension with rituximab that resolved after decreasing the infusion rate. There were no reported infections two yr after treatment, and all of the viral monitoring in these patients remained negative.
KW - adolescents
KW - anti-HLA antibody
KW - antibodies
KW - antibody mediated rejection
KW - outcome
KW - pediatric kidney transplant
UR - http://www.scopus.com/inward/record.url?scp=84885431062&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84885431062&partnerID=8YFLogxK
U2 - 10.1111/petr.12129
DO - 10.1111/petr.12129
M3 - Article
C2 - 23901848
AN - SCOPUS:84885431062
SN - 1397-3142
VL - 17
SP - E149-E155
JO - Pediatric Transplantation
JF - Pediatric Transplantation
IS - 7
ER -