Acute bacterial cholangitis

Mamta K. Jain, Rajeev Jain

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Acute bacterial cholangitis refers to a bacterial infection of the biliary tract. Choledocholithiasis is the most common cause of biliary obstruction, with Escherichia coli, Klebsiella spp, and Enterococcus spp the most frequent biliary pathogens isolated in patients with cholangitis. Clinical presentation varies from mild illness to septic shock. The diagnosis of cholangitis is clinical and is supported by laboratory and radiographic findings. Initial treatment is supportive and includes antibiotics to cover the typical pathogens, but definitive treatment requires biliary drainage. Endoscopic retrograde cholangiopancreatography (ERCP) is the preferred technique to achieve biliary decompression with placement of an internal or nasobiliary stent. In cases in which ERCP is unsuccessfut or technically not feasible, percutaneous transhepatic biliary drainage (PTBD) is preferred over surgery, which carries significant morbidity and mortality. In order to prevent post-ERCP cholangitis, prophylactic antibiotics are recommended in patients undergoing ERCP for known or suspected biliary obstruction.

Original languageEnglish (US)
Pages (from-to)113-121
Number of pages9
JournalCurrent Treatment Options in Gastroenterology
Volume9
Issue number2
DOIs
StatePublished - Apr 2006

Fingerprint

Cholangitis
Endoscopic Retrograde Cholangiopancreatography
Drainage
Anti-Bacterial Agents
Choledocholithiasis
Klebsiella
Enterococcus
Biliary Tract
Septic Shock
Decompression
Bacterial Infections
Stents
Escherichia coli
Morbidity
Mortality
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Acute bacterial cholangitis. / Jain, Mamta K.; Jain, Rajeev.

In: Current Treatment Options in Gastroenterology, Vol. 9, No. 2, 04.2006, p. 113-121.

Research output: Contribution to journalArticle

Jain, Mamta K. ; Jain, Rajeev. / Acute bacterial cholangitis. In: Current Treatment Options in Gastroenterology. 2006 ; Vol. 9, No. 2. pp. 113-121.
@article{425c49f1ebea4e7f93af1bb557064129,
title = "Acute bacterial cholangitis",
abstract = "Acute bacterial cholangitis refers to a bacterial infection of the biliary tract. Choledocholithiasis is the most common cause of biliary obstruction, with Escherichia coli, Klebsiella spp, and Enterococcus spp the most frequent biliary pathogens isolated in patients with cholangitis. Clinical presentation varies from mild illness to septic shock. The diagnosis of cholangitis is clinical and is supported by laboratory and radiographic findings. Initial treatment is supportive and includes antibiotics to cover the typical pathogens, but definitive treatment requires biliary drainage. Endoscopic retrograde cholangiopancreatography (ERCP) is the preferred technique to achieve biliary decompression with placement of an internal or nasobiliary stent. In cases in which ERCP is unsuccessfut or technically not feasible, percutaneous transhepatic biliary drainage (PTBD) is preferred over surgery, which carries significant morbidity and mortality. In order to prevent post-ERCP cholangitis, prophylactic antibiotics are recommended in patients undergoing ERCP for known or suspected biliary obstruction.",
author = "Jain, {Mamta K.} and Rajeev Jain",
year = "2006",
month = "4",
doi = "10.1007/s11938-006-0030-7",
language = "English (US)",
volume = "9",
pages = "113--121",
journal = "Current Treatment Options in Gastroenterology",
issn = "1092-8472",
publisher = "Current Science, Inc.",
number = "2",

}

TY - JOUR

T1 - Acute bacterial cholangitis

AU - Jain, Mamta K.

AU - Jain, Rajeev

PY - 2006/4

Y1 - 2006/4

N2 - Acute bacterial cholangitis refers to a bacterial infection of the biliary tract. Choledocholithiasis is the most common cause of biliary obstruction, with Escherichia coli, Klebsiella spp, and Enterococcus spp the most frequent biliary pathogens isolated in patients with cholangitis. Clinical presentation varies from mild illness to septic shock. The diagnosis of cholangitis is clinical and is supported by laboratory and radiographic findings. Initial treatment is supportive and includes antibiotics to cover the typical pathogens, but definitive treatment requires biliary drainage. Endoscopic retrograde cholangiopancreatography (ERCP) is the preferred technique to achieve biliary decompression with placement of an internal or nasobiliary stent. In cases in which ERCP is unsuccessfut or technically not feasible, percutaneous transhepatic biliary drainage (PTBD) is preferred over surgery, which carries significant morbidity and mortality. In order to prevent post-ERCP cholangitis, prophylactic antibiotics are recommended in patients undergoing ERCP for known or suspected biliary obstruction.

AB - Acute bacterial cholangitis refers to a bacterial infection of the biliary tract. Choledocholithiasis is the most common cause of biliary obstruction, with Escherichia coli, Klebsiella spp, and Enterococcus spp the most frequent biliary pathogens isolated in patients with cholangitis. Clinical presentation varies from mild illness to septic shock. The diagnosis of cholangitis is clinical and is supported by laboratory and radiographic findings. Initial treatment is supportive and includes antibiotics to cover the typical pathogens, but definitive treatment requires biliary drainage. Endoscopic retrograde cholangiopancreatography (ERCP) is the preferred technique to achieve biliary decompression with placement of an internal or nasobiliary stent. In cases in which ERCP is unsuccessfut or technically not feasible, percutaneous transhepatic biliary drainage (PTBD) is preferred over surgery, which carries significant morbidity and mortality. In order to prevent post-ERCP cholangitis, prophylactic antibiotics are recommended in patients undergoing ERCP for known or suspected biliary obstruction.

UR - http://www.scopus.com/inward/record.url?scp=33645524936&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645524936&partnerID=8YFLogxK

U2 - 10.1007/s11938-006-0030-7

DO - 10.1007/s11938-006-0030-7

M3 - Article

C2 - 16539872

AN - SCOPUS:33645524936

VL - 9

SP - 113

EP - 121

JO - Current Treatment Options in Gastroenterology

JF - Current Treatment Options in Gastroenterology

SN - 1092-8472

IS - 2

ER -