Acute coronary syndrome patients with depression have low blood cell membrane omega-3 fatty acid levels

Alpesh A. Amin, Rishi A. Menon, Kimberly J. Reid, William S. Harris, John A. Spertus

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Objective: To determine the extent to which levels of membrane eicosapentaenoic (EPA)+docosahexaenoic acids (DHA) (the omega-3 index) were associated with depression in patients with acute coronary syndrome (ACS). Depression is associated with worse cardiovascular (CV) outcomes in patients with ACS. Reduced levels of blood cell membrane omega-3 (n-3) fatty acids (FAs), an emerging risk factor for both CV disease and depression, may help to explain the link between depression and adverse CV outcomes. Methods: We measured membrane FA composition in 759 patients with confirmed ACS. The analysis included not only EPA and DHA but also the n-6 FAs linoleic and arachidonic acids (LA and AA). Depressive symptoms were measured with the Patient Health Questionnaire-9 (PHQ). Multivariable linear regression was used to adjust for demographic and clinical characteristics. Results: There was a significant inverse relationship between the n-3 index and depressive symptoms (PHQ) in the fully adjusted model (p =.034). For every 4.54% point rise in the n-3 index, there was a 1-point decline in depressive symptoms. In contrast to the n-3 FAs, membrane levels of the n-6 FAs LA and AA were not different between depressed and nondepressed ACS patients. Conclusion: We found an inverse relationship between the n-3 index and the prevalence of depressive symptoms in patients with ACS. Therefore, this study supports the hypothesis that reduced n-3 FA tissue levels are a common and potentially modifiable link between depression and adverse CV outcomes.

Original languageEnglish (US)
Pages (from-to)856-862
Number of pages7
JournalPsychosomatic Medicine
Volume70
Issue number8
DOIs
StatePublished - Oct 2008

Keywords

  • Acute coronary syndrome
  • Depression
  • Omega-3 fatty acids

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health

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