Akute disseminierte enzephalomyelitis. Pathogenese, diagnose, behandlung und prognose

Translated title of the contribution: Acute disseminated encephalomyelitis. Pathogenesis, diagnosis, treatment, and prognosis

O. Stüve, S. Nessler, H. P. Hartung, B. Hemmer, H. Wiendl, B. C. Kieseier

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Acute disseminated encephalomyelitis (ADEM) is typically a monophasic, demyelinating disease of the CNS that predominantly affects children. Typically, its clinical symptoms follow an infection or vaccination. In this regard, numerous viral and bacterial pathogens as well as several vaccinations have been associated with ADEM. Studies from animal models suggest that primary and secondary autoimmune responses may contribute to CNS inflammation and demyelination in ADEM. The diagnosis of ADEM is strongly suggested by a close temporal relationship between a viral infection or immunization and the onset of neurologic symptoms, and it is supported by extensive, multifocal, subcortical white-matter disease on brain magnetic resonance imaging. While mild lymphocytic pleocytosis and elevated proteins are detectable in the CSF in ADEM, oligoclonal bands are not always present. Treatment of this disorder consists of anti-inflammatory and immunosuppressive therapies, and the prognosis is generally considered favorable.

Translated title of the contributionAcute disseminated encephalomyelitis. Pathogenesis, diagnosis, treatment, and prognosis
Original languageGerman
Pages (from-to)701-707
Number of pages7
JournalNervenarzt
Volume76
Issue number6
DOIs
StatePublished - Jun 1 2005

Keywords

  • Acute disseminated encephalomyelitis
  • Central nervous system
  • Experimental autoimmune encephalomyelitis
  • Infections
  • Multiple sclerosis
  • Theiler's murine encephalomyelitis
  • Vaccinations

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

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