Acute effects of drug abuse in schizophrenic patients: Clinical observations and patients' self-reports

Lisa Dixon, Gretchen Haas, Peter Weiden, John Sweeney, Allen Frances

Research output: Contribution to journalArticle

175 Scopus citations


Substance abuse among schizophrenic patients is an increasingly recognized clinical phenomenon. The authors review experimental and observed clinical effects of drug abuse and patients' subjective experiences of acute intoxication. Though drug abuse may exacerbate psychotic symptoms, abused drugs may also lead to transient symptom reduction in subgroups of schizophrenic patients. Some patients report feeling less dysphoric, less anxious, and more energetic while intoxicated. Models of the relationship of drug abuse and schizophrenia, particularly the self-medication hypothesis, are discussed in reference to these data.

Original languageEnglish (US)
Pages (from-to)69-79
Number of pages11
JournalSchizophrenia bulletin
Issue number1
StatePublished - Dec 1 1990


ASJC Scopus subject areas

  • Psychiatry and Mental health

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