Acute ethanol intoxication increases the risk of infection following penetrating abdominal trauma

L. M. Gentilello, R. A. Cobean, A. P. Walker, E. E. Moore, M. J. Wertz, E. P. Dellinger

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Acute alcohol (ETOH) intoxication as a risk factor for infection in trauma victims to our knowledge has not been previously reported. To determine if ETOH intoxication increases infection risk we examined data from 365 patients with penetrating abdominal trauma who were enrolled in a multi-center antibiotic study. Ninety-four patients sustained an injury to a hollow viscus. To separate acute from chronic ETOH effects, infections were divided into two categories: (1) trauma related; infections caused by bacterial contamination at the time of injury, while blood alcohol level (BAL) was elevated. (2) nosocomial; infections caused by bacteria acquired during hospital stay, after BAL had normalized. A BAL ≥200 mg/dL was associated with a 2.6-fold increase in trauma-related infections. There was no association between BAL and subsequent nosocomial infection. Since infection rates for intoxicated patients were not higher after BAL had normalized, acute rather than chronic effects of ETOH appear to be responsible.

Original languageEnglish (US)
Pages (from-to)669-675
Number of pages7
JournalJournal of Trauma
Volume34
Issue number5
StatePublished - 1993

Fingerprint

Ethanol
Wounds and Injuries
Infection
Alcoholic Intoxication
Viscera
Cross Infection
Bacterial Infections
Length of Stay
Blood Alcohol Content
Anti-Bacterial Agents
Bacteria

ASJC Scopus subject areas

  • Surgery

Cite this

Gentilello, L. M., Cobean, R. A., Walker, A. P., Moore, E. E., Wertz, M. J., & Dellinger, E. P. (1993). Acute ethanol intoxication increases the risk of infection following penetrating abdominal trauma. Journal of Trauma, 34(5), 669-675.

Acute ethanol intoxication increases the risk of infection following penetrating abdominal trauma. / Gentilello, L. M.; Cobean, R. A.; Walker, A. P.; Moore, E. E.; Wertz, M. J.; Dellinger, E. P.

In: Journal of Trauma, Vol. 34, No. 5, 1993, p. 669-675.

Research output: Contribution to journalArticle

Gentilello, LM, Cobean, RA, Walker, AP, Moore, EE, Wertz, MJ & Dellinger, EP 1993, 'Acute ethanol intoxication increases the risk of infection following penetrating abdominal trauma', Journal of Trauma, vol. 34, no. 5, pp. 669-675.
Gentilello, L. M. ; Cobean, R. A. ; Walker, A. P. ; Moore, E. E. ; Wertz, M. J. ; Dellinger, E. P. / Acute ethanol intoxication increases the risk of infection following penetrating abdominal trauma. In: Journal of Trauma. 1993 ; Vol. 34, No. 5. pp. 669-675.
@article{b641b0bc685846abaeaa2fe7720dc101,
title = "Acute ethanol intoxication increases the risk of infection following penetrating abdominal trauma",
abstract = "Acute alcohol (ETOH) intoxication as a risk factor for infection in trauma victims to our knowledge has not been previously reported. To determine if ETOH intoxication increases infection risk we examined data from 365 patients with penetrating abdominal trauma who were enrolled in a multi-center antibiotic study. Ninety-four patients sustained an injury to a hollow viscus. To separate acute from chronic ETOH effects, infections were divided into two categories: (1) trauma related; infections caused by bacterial contamination at the time of injury, while blood alcohol level (BAL) was elevated. (2) nosocomial; infections caused by bacteria acquired during hospital stay, after BAL had normalized. A BAL ≥200 mg/dL was associated with a 2.6-fold increase in trauma-related infections. There was no association between BAL and subsequent nosocomial infection. Since infection rates for intoxicated patients were not higher after BAL had normalized, acute rather than chronic effects of ETOH appear to be responsible.",
author = "Gentilello, {L. M.} and Cobean, {R. A.} and Walker, {A. P.} and Moore, {E. E.} and Wertz, {M. J.} and Dellinger, {E. P.}",
year = "1993",
language = "English (US)",
volume = "34",
pages = "669--675",
journal = "Journal of Trauma and Acute Care Surgery",
issn = "2163-0755",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Acute ethanol intoxication increases the risk of infection following penetrating abdominal trauma

AU - Gentilello, L. M.

AU - Cobean, R. A.

AU - Walker, A. P.

AU - Moore, E. E.

AU - Wertz, M. J.

AU - Dellinger, E. P.

PY - 1993

Y1 - 1993

N2 - Acute alcohol (ETOH) intoxication as a risk factor for infection in trauma victims to our knowledge has not been previously reported. To determine if ETOH intoxication increases infection risk we examined data from 365 patients with penetrating abdominal trauma who were enrolled in a multi-center antibiotic study. Ninety-four patients sustained an injury to a hollow viscus. To separate acute from chronic ETOH effects, infections were divided into two categories: (1) trauma related; infections caused by bacterial contamination at the time of injury, while blood alcohol level (BAL) was elevated. (2) nosocomial; infections caused by bacteria acquired during hospital stay, after BAL had normalized. A BAL ≥200 mg/dL was associated with a 2.6-fold increase in trauma-related infections. There was no association between BAL and subsequent nosocomial infection. Since infection rates for intoxicated patients were not higher after BAL had normalized, acute rather than chronic effects of ETOH appear to be responsible.

AB - Acute alcohol (ETOH) intoxication as a risk factor for infection in trauma victims to our knowledge has not been previously reported. To determine if ETOH intoxication increases infection risk we examined data from 365 patients with penetrating abdominal trauma who were enrolled in a multi-center antibiotic study. Ninety-four patients sustained an injury to a hollow viscus. To separate acute from chronic ETOH effects, infections were divided into two categories: (1) trauma related; infections caused by bacterial contamination at the time of injury, while blood alcohol level (BAL) was elevated. (2) nosocomial; infections caused by bacteria acquired during hospital stay, after BAL had normalized. A BAL ≥200 mg/dL was associated with a 2.6-fold increase in trauma-related infections. There was no association between BAL and subsequent nosocomial infection. Since infection rates for intoxicated patients were not higher after BAL had normalized, acute rather than chronic effects of ETOH appear to be responsible.

UR - http://www.scopus.com/inward/record.url?scp=0027246603&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027246603&partnerID=8YFLogxK

M3 - Article

VL - 34

SP - 669

EP - 675

JO - Journal of Trauma and Acute Care Surgery

JF - Journal of Trauma and Acute Care Surgery

SN - 2163-0755

IS - 5

ER -