Induction of acute hypervitaminosis A in the guinea pig can substantially suppress delayed-type hypersensitivity and Arthus reactivity of moderate intensity and the inflammatory response to intradermal injection of diphtheria toxin. No effect of Vit. A was demonstrated on the clearance of bacteriophage φX 174 from the circulation or on antibody formation to the phage. The results suggest that acute hypervitaminosis A can suppress inflammatory responses of moderate intensity in the skin of guinea pigs, possibly as a consequence of an action on lysosomes.
|Original language||English (US)|
|Number of pages||5|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Feb 1963|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)