Acute Hypervitaminosis A in Guinea Pigs. II. Effects on Delayed-Type Hypersensitivity

J. W. UHR, G. WEISSMANN, L. THOMAS

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Induction of acute hypervitaminosis A in the guinea pig can substantially suppress delayed-type hypersensitivity and Arthus reactivity of moderate intensity and the inflammatory response to intradermal injection of diphtheria toxin. No effect of Vit. A was demonstrated on the clearance of bacteriophage φX 174 from the circulation or on antibody formation to the phage. The results suggest that acute hypervitaminosis A can suppress inflammatory responses of moderate intensity in the skin of guinea pigs, possibly as a consequence of an action on lysosomes.

Original languageEnglish (US)
Pages (from-to)287-291
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume112
Issue number2
DOIs
StatePublished - Feb 1963

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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