Acute kidney injury: Current perspectives

Devasmita Choudhury

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Acute kidney injury (AKI) increases morbidity and mortality, particularly for the critically ill. Recent definitions standardizing AKI to reflect graded changes in serum creatinine and urine output (per the Risk, Injury, Failure, Loss, and End-stage renal failure [RIFLE] and Acute Kidney Injury Network [AKIN] criteria) with severity of renal injury and developments in AKI pathobiology are being utilized to identify biomarkers of early kidney injury. These developments may be useful in the early intervention of preventing AKI. Although there has been progress in the management of AKI, therapeutic challenges include appropriate prophylaxis prior to contrast administration, use of diuretics, vasopressors, and the type and dose of renal replacement therapy. Future use of bioartificial dialyzers, plasma therapies, and the possibility of stem cell regeneration of injured kidney tissue are being actively investigated to provide alternative treatment options for AKI. This RE aims to provide an overview of current practices, available therapies, and continued research in AKI therapy.

Original languageEnglish (US)
Pages (from-to)29-40
Number of pages12
JournalPostgraduate medicine
Volume122
Issue number6
DOIs
StatePublished - Nov 1 2010

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Keywords

  • Acute kidney injury
  • Comorbidities
  • Critically ill
  • Kidney failure
  • Renal failure

ASJC Scopus subject areas

  • Medicine(all)

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