Acute leukemia with B-lymphoid and myeloid differentiation associated with an inv(5)(q13q33) in an adult patient

Brad W. Butcher; Kathleen S. Wilson; Steven H. Kroft; Robert H. Collins; Vikas Bhushan

doi:10.1016/j.cancergencyto.2004.05.006

Acute leukemia with B-lymphoid and myeloid differentiation associated with an inv(5)(q13q33) in an adult patient

Brad W. Butcher, Kathleen S. Wilson, Steven H. Kroft, Robert H. Collins, Vikas Bhushan

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7 Scopus citations

Abstract

A paracentric inversion in the long arm of chromosome 5, inv(5)(q13q33), was found as a clonal abnormality in a patient with a treatment-resistant biphenotypic acute leukemia with B-lymphoid and myeloid differentiation. This cytogenetic aberration has not been reported previously in biphenotypic acute leukemia, although rearrangements of chromosome bands q13 and q33 have been implicated in the development of several hematologic malignancies. The presence of this aberration as the sole chromosomal abnormality suggests an important role in the pathogenesis of biphenotypic acute leukemia.

Original language	English (US)
Pages (from-to)	62-66
Number of pages	5
Journal	Cancer Genetics and Cytogenetics
Volume	157
Issue number	1
DOIs	https://doi.org/10.1016/j.cancergencyto.2004.05.006
State	Published - Feb 2005

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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10.1016/j.cancergencyto.2004.05.006

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abstract = "A paracentric inversion in the long arm of chromosome 5, inv(5)(q13q33), was found as a clonal abnormality in a patient with a treatment-resistant biphenotypic acute leukemia with B-lymphoid and myeloid differentiation. This cytogenetic aberration has not been reported previously in biphenotypic acute leukemia, although rearrangements of chromosome bands q13 and q33 have been implicated in the development of several hematologic malignancies. The presence of this aberration as the sole chromosomal abnormality suggests an important role in the pathogenesis of biphenotypic acute leukemia.",

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AU - Collins, Robert H.

AU - Bhushan, Vikas

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AB - A paracentric inversion in the long arm of chromosome 5, inv(5)(q13q33), was found as a clonal abnormality in a patient with a treatment-resistant biphenotypic acute leukemia with B-lymphoid and myeloid differentiation. This cytogenetic aberration has not been reported previously in biphenotypic acute leukemia, although rearrangements of chromosome bands q13 and q33 have been implicated in the development of several hematologic malignancies. The presence of this aberration as the sole chromosomal abnormality suggests an important role in the pathogenesis of biphenotypic acute leukemia.

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Acute leukemia with B-lymphoid and myeloid differentiation associated with an inv(5)(q13q33) in an adult patient

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