Acute Leukemias of Ambiguous Lineage: Clarification on Lineage Specificity

Jason H. Kurzer, Olga K. Weinberg

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Acute leukemias of ambiguous lineage (ALAL) include acute undifferentiated leukemia and mixed-phenotype acute leukemia (MPAL). This article provides an overview of the diagnosis of ALAL and focuses on the data accounting for the current lineage-assignment criteria for blasts harboring more than one lineage-associated marker. In addition, the currently known molecular data are reviewed, which show that MPAL-associated gene mutations, methylation signatures, and expression profiles are a mixture of those seen in both acute myeloid leukemia and acute lymphoblastic leukemia. Finally, the prognosis and current treatments of MPAL are briefly discussed.

Original languageEnglish (US)
Pages (from-to)687-697
Number of pages11
JournalSurgical Pathology Clinics
Issue number3
StatePublished - Sep 2019
Externally publishedYes


  • Acute undifferentiated leukemia
  • KMT2A
  • Lineage
  • Mixed phenotype acute leukemia

ASJC Scopus subject areas

  • Surgery
  • Pathology and Forensic Medicine


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