TY - JOUR
T1 - Acute myeloid leukaemia with FLT3 gene mutations of both internal tandem duplication and point mutation type
AU - Chen, Weina
AU - Jones, Dan
AU - Jeffrey Medeiros, L.
AU - Luthra, Rajyalashmi
AU - Lin, Pei
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2005/9
Y1 - 2005/9
N2 - FLT3 gene mutations, either internal tandem duplication or point mutation type, are common in acute myeloid leukaemia (AML). We describe 21 AML cases with both types of gene mutations, so-called dual mutations, representing approximately 1% of all cases. Most newly diagnosed AML with FLT3 dual mutations had monocytic differentiation and a normal karyotype. Over the disease course, changes in FLT3 mutation status were seen in 89% of cases, and were associated with cytogenetic changes. We conclude that FLT3 dual mutations occur rarely in AML, and appear to be related to clonal evolution.
AB - FLT3 gene mutations, either internal tandem duplication or point mutation type, are common in acute myeloid leukaemia (AML). We describe 21 AML cases with both types of gene mutations, so-called dual mutations, representing approximately 1% of all cases. Most newly diagnosed AML with FLT3 dual mutations had monocytic differentiation and a normal karyotype. Over the disease course, changes in FLT3 mutation status were seen in 89% of cases, and were associated with cytogenetic changes. We conclude that FLT3 dual mutations occur rarely in AML, and appear to be related to clonal evolution.
KW - Acute myeloid leukaemia
KW - Cytogenetics
KW - FLT3 gene
KW - Internal tandem duplications
KW - Point mutations
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U2 - 10.1111/j.1365-2141.2005.05666.x
DO - 10.1111/j.1365-2141.2005.05666.x
M3 - Article
C2 - 16115128
AN - SCOPUS:27244453278
SN - 0007-1048
VL - 130
SP - 726
EP - 728
JO - British Journal of Haematology
JF - British Journal of Haematology
IS - 5
ER -