Abstract
Objectives: Recurrent cytogenetic abnormalities and/or molecular aberrations play an important role in the diagnosis and prognostification of acute myeloid leukemia (AML). We describe a case of a 40 year old woman diagnosed with de novo AML with a novel t(7;14)(q21,q32) and trisomy 4 with poor clinical outcome. Methods: Morphologic, flow cytometry and cytogenetic results of the patient’s peripheral blood and bone marrow samples were analyzed. Results: The diagnostic bone marrow was hypercellular for age (>95%) with increased blasts (62%) that by flow cytometry exhibited myeloid differentiation with a few T/NK lineage markers. Cytogenetics showed a t(7;14)(q21,q32) and trisomy 4. The patient had extremely poor response to two rounds of induction chemotherapy with persistent leukemia following therapy. Conclusion: To the best of our knowledge, the t(7;14) is a novel cytogenetic abnormality that has not been reported previously in acute myeloid leukemia, and is important to report as it appears to be associated with poor prognosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 376-380 |
| Number of pages | 5 |
| Journal | Lab Medicine |
| Volume | 48 |
| Issue number | 4 |
| DOIs | |
| State | Published - Nov 1 2017 |
Keywords
- cytogenetic
- leukemia
- myeloid
- t(7;14)
- trisomy 4
ASJC Scopus subject areas
- General Medicine