Acute-On-Chronic Liver Failure

Sumeet K. Asrani; Jacqueline G. O'Leary

doi:10.1016/j.cld.2014.05.004

Acute-On-Chronic Liver Failure

Sumeet K. Asrani, Jacqueline G. O'Leary

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

The Model for End-Stage Liver Disease (MELD) has been the single best predictor of outcome of the progression of cirrhosis. Acute-on-chronic liver failure (ACLF) has been proposed as an alternative path in the natural history of cirrhosis. ACLF occurs in patients with chronic liver disease and is characterized by a precipitating event, resulting in acute deterioration in liver function, multiorgan system failure, and high short-term mortality. In this review, the natural course of patients with ACLF, especially as it relates to management of cirrhotic patients on the transplant waiting list, and its impact on liver transplantation outcomes are defined.

Original language	English (US)
Pages (from-to)	561-574
Number of pages	14
Journal	Clinics in Liver Disease
Volume	18
Issue number	3
DOIs	https://doi.org/10.1016/j.cld.2014.05.004
State	Published - Aug 2014

Keywords

Acute liver failure
Acute-on-chronic liver failure
Cirrhosis
Liver transplantation
Organ failure

ASJC Scopus subject areas

Hepatology

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10.1016/j.cld.2014.05.004

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title = "Acute-On-Chronic Liver Failure",

abstract = "The Model for End-Stage Liver Disease (MELD) has been the single best predictor of outcome of the progression of cirrhosis. Acute-on-chronic liver failure (ACLF) has been proposed as an alternative path in the natural history of cirrhosis. ACLF occurs in patients with chronic liver disease and is characterized by a precipitating event, resulting in acute deterioration in liver function, multiorgan system failure, and high short-term mortality. In this review, the natural course of patients with ACLF, especially as it relates to management of cirrhotic patients on the transplant waiting list, and its impact on liver transplantation outcomes are defined.",

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AU - Asrani, Sumeet K.

AU - O'Leary, Jacqueline G.

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AB - The Model for End-Stage Liver Disease (MELD) has been the single best predictor of outcome of the progression of cirrhosis. Acute-on-chronic liver failure (ACLF) has been proposed as an alternative path in the natural history of cirrhosis. ACLF occurs in patients with chronic liver disease and is characterized by a precipitating event, resulting in acute deterioration in liver function, multiorgan system failure, and high short-term mortality. In this review, the natural course of patients with ACLF, especially as it relates to management of cirrhotic patients on the transplant waiting list, and its impact on liver transplantation outcomes are defined.

KW - Acute liver failure

KW - Acute-on-chronic liver failure

KW - Cirrhosis

KW - Liver transplantation

KW - Organ failure

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Acute-On-Chronic Liver Failure

Abstract

Keywords

ASJC Scopus subject areas

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