Acute Sirolimus Pulmonary Toxicity in an Infant Heart Transplant Recipient: Case Report and Literature Review

Bibhuti B. Das, Lawrence Shoemaker, Sujata Subramanian, Christopher Johnsrude, Michael Recto, Erle H. Austin

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Sirolimus-associated pulmonary disease should be considered in the differential diagnosis of acute respiratory distress syndrome in transplant recipients receiving this drug. It represents a rare, potentially lethal, and yet reversible adverse effect. We report the case an infant who presented with acute respiratory distress 57 days after heart transplantation 3 days after starting sirolimus. The acute presentation and prompt resolution after discontinuation of this drug suggest a direct toxic effect to the lungs. To our knowledge, this is the first published pediatric description of this syndrome after heart transplantation.

Original languageEnglish (US)
Pages (from-to)296-298
Number of pages3
JournalJournal of Heart and Lung Transplantation
Volume26
Issue number3
DOIs
StatePublished - Mar 2007

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Transplantation

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