Adaptation of antiretroviral therapy in human immunodeficiency virus infection with central nervous system involvement

Matthias Mehling, Henning Drechsler, Jens Kuhle, Martin Hardmeier, Ruediger Doerries, Stephan Ruegg, Achim Gass

Research output: Contribution to journalArticle

7 Scopus citations


The authors describe a patient with known human immunodeficiency virus (HIV)-1 infection who presented with two generalized seizures and was found to have extensive white matter disease and a left/bilateral temporo-occipital focal slowing on electroencephalography (EEG). There were no magnetic resonance imaging (MRI) or cerebrospinal fluid (CSF) indications for opportunistic infection. Plasma viremia was controlled, whereas viral replication was uncontrolled in CSF. CSF-specific genotype-guided adaptation of the antiretroviral therapy in order to optimize central nervous system (CNS) penetration resulted in clinical improvement and normalization of MRI and EEG. Our case report illustrates the importance of individualized antiretroviral therapy in HIV infected patients with neurological complications.

Original languageEnglish (US)
Pages (from-to)78-84
Number of pages7
JournalJournal of NeuroVirology
Issue number1
StatePublished - Mar 1 2008



  • Antiretroviral therapy CNS
  • CNS infection
  • HIV
  • HIV epilepsy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

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