Adaptive mechanisms that preserve cardiac function in mice without myoglobin

A. P. Meeson, N. Radford, J. M. Shelton, P. P A Mammen, J. M. DiMaio, K. Hutcheson, Y. Kong, J. Elterman, R. S. Williams, D. J. Garry

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Mice lacking myoglobin survive to adulthood and meet the circulatory demands of exercise and pregnancy without cardiac decompensation. In the present study, we show that many myoglobin-deficient embryos die in utero at midgestation with signs of cardiac failure. Fetal mice that survive to gestational day 12.5, however, suffer no subsequent excess mortality. Survival in the absence of myoglobin is associated with increased vascularity and the induction of genes encoding the hypoxia-inducible transcription factors 1 α and 2, stress proteins such as heat shock protein 27, and vascular endothelial growth factor. These adaptations are evident in late fetal life, persist into adulthood, and are sufficient to maintain normal myocardial oxygen consumption during stressed conditions. These data reveal that myoglobin is necessary to support cardiac function during development, but adaptive responses evoked in some animals can fully compensate for the defect in cellular oxygen transport resulting from the loss of myoglobin.

Original languageEnglish (US)
Pages (from-to)713-720
Number of pages8
JournalCirculation Research
Volume88
Issue number7
StatePublished - Apr 13 2001

Fingerprint

Myoglobin
HSP27 Heat-Shock Proteins
Hypoxia-Inducible Factor 1
Heat-Shock Proteins
Oxygen Consumption
Vascular Endothelial Growth Factor A
Transcription Factors
Embryonic Structures
Heart Failure
Oxygen
Pregnancy
Mortality
Genes

Keywords

  • Hypoxia
  • Metabolism
  • Myoglobin
  • Transgenic mice
  • Vasculature

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Meeson, A. P., Radford, N., Shelton, J. M., Mammen, P. P. A., DiMaio, J. M., Hutcheson, K., ... Garry, D. J. (2001). Adaptive mechanisms that preserve cardiac function in mice without myoglobin. Circulation Research, 88(7), 713-720.

Adaptive mechanisms that preserve cardiac function in mice without myoglobin. / Meeson, A. P.; Radford, N.; Shelton, J. M.; Mammen, P. P A; DiMaio, J. M.; Hutcheson, K.; Kong, Y.; Elterman, J.; Williams, R. S.; Garry, D. J.

In: Circulation Research, Vol. 88, No. 7, 13.04.2001, p. 713-720.

Research output: Contribution to journalArticle

Meeson, AP, Radford, N, Shelton, JM, Mammen, PPA, DiMaio, JM, Hutcheson, K, Kong, Y, Elterman, J, Williams, RS & Garry, DJ 2001, 'Adaptive mechanisms that preserve cardiac function in mice without myoglobin', Circulation Research, vol. 88, no. 7, pp. 713-720.
Meeson AP, Radford N, Shelton JM, Mammen PPA, DiMaio JM, Hutcheson K et al. Adaptive mechanisms that preserve cardiac function in mice without myoglobin. Circulation Research. 2001 Apr 13;88(7):713-720.
Meeson, A. P. ; Radford, N. ; Shelton, J. M. ; Mammen, P. P A ; DiMaio, J. M. ; Hutcheson, K. ; Kong, Y. ; Elterman, J. ; Williams, R. S. ; Garry, D. J. / Adaptive mechanisms that preserve cardiac function in mice without myoglobin. In: Circulation Research. 2001 ; Vol. 88, No. 7. pp. 713-720.
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