Adaptive metabolic changes in CADASIL white matter

Tamar Akhvlediani, Anke Henning, Peter S. Sándor, Peter Boesiger, Hans H. Jung

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an important genetic cause of stroke, but pathogenic mechanisms and functional alterations remain poorly characterized. The purpose of this study was to investigate adaptive metabolic and functional changes in white matter hyperintensities and normal-appearing white matter in CADASIL patients using 1H-magnetic resonance spectroscopic imaging (MRSI). Eight CADASIL patients and eight matched healthy controls were studied. 1H-MRSI data were acquired on a 3T scanner using high-resolution multi-spin echo spectroscopic imaging (T E = 288 ms) and non-accelerated medium-resolution MRSI (T E = 35 ms). MRI of all CADASIL patients demonstrated characteristic white matter hyper-intensities (WMH) in the subcortical periventricular white matter. Cre/Cho, Glx/Cho and Glx/Cre ratios were significantly decreased in WMH compared to normal-appearing white matter (NAWM) in patients, while Glx/Cre and mI/Cho ratios in NAWM showed a significant increase compared to healthy controls. In severely affected patients derived spectra reflected a decrease of NAA concentrations inside WMH when compared to healthy white matter. Metabolic abnormalities in WMH of CADASIL patients are compatible with axonal loss due to chronic micro-infarctions. Increased Glx/Cre and mI/Cho ratios in NAWM indicate an augmented glial cell density and decreased neuronal cell density. This altered tissue composition might be interpreted as adaptation to hypoperfusion and impaired vasoreactivity in NAWM of CADASIL patients. Our data might contribute to the general understanding of adaptive processes induced by hypoperfusion and chronic ischemia.

Original languageEnglish (US)
Pages (from-to)171-177
Number of pages7
JournalJournal of Neurology
Volume257
Issue number2
DOIs
StatePublished - Feb 1 2010
Externally publishedYes

Fingerprint

CADASIL
Magnetic Resonance Imaging
White Matter
Cell Count
Neuroglia
Infarction

Keywords

  • CADASIL
  • FMRI
  • Magnetic resonance spectroscopy
  • MRSI

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Akhvlediani, T., Henning, A., Sándor, P. S., Boesiger, P., & Jung, H. H. (2010). Adaptive metabolic changes in CADASIL white matter. Journal of Neurology, 257(2), 171-177. https://doi.org/10.1007/s00415-009-5281-5

Adaptive metabolic changes in CADASIL white matter. / Akhvlediani, Tamar; Henning, Anke; Sándor, Peter S.; Boesiger, Peter; Jung, Hans H.

In: Journal of Neurology, Vol. 257, No. 2, 01.02.2010, p. 171-177.

Research output: Contribution to journalArticle

Akhvlediani, T, Henning, A, Sándor, PS, Boesiger, P & Jung, HH 2010, 'Adaptive metabolic changes in CADASIL white matter', Journal of Neurology, vol. 257, no. 2, pp. 171-177. https://doi.org/10.1007/s00415-009-5281-5
Akhvlediani, Tamar ; Henning, Anke ; Sándor, Peter S. ; Boesiger, Peter ; Jung, Hans H. / Adaptive metabolic changes in CADASIL white matter. In: Journal of Neurology. 2010 ; Vol. 257, No. 2. pp. 171-177.
@article{33acfb6fbbe34b8490a8a988bc915ddb,
title = "Adaptive metabolic changes in CADASIL white matter",
abstract = "Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an important genetic cause of stroke, but pathogenic mechanisms and functional alterations remain poorly characterized. The purpose of this study was to investigate adaptive metabolic and functional changes in white matter hyperintensities and normal-appearing white matter in CADASIL patients using 1H-magnetic resonance spectroscopic imaging (MRSI). Eight CADASIL patients and eight matched healthy controls were studied. 1H-MRSI data were acquired on a 3T scanner using high-resolution multi-spin echo spectroscopic imaging (T E = 288 ms) and non-accelerated medium-resolution MRSI (T E = 35 ms). MRI of all CADASIL patients demonstrated characteristic white matter hyper-intensities (WMH) in the subcortical periventricular white matter. Cre/Cho, Glx/Cho and Glx/Cre ratios were significantly decreased in WMH compared to normal-appearing white matter (NAWM) in patients, while Glx/Cre and mI/Cho ratios in NAWM showed a significant increase compared to healthy controls. In severely affected patients derived spectra reflected a decrease of NAA concentrations inside WMH when compared to healthy white matter. Metabolic abnormalities in WMH of CADASIL patients are compatible with axonal loss due to chronic micro-infarctions. Increased Glx/Cre and mI/Cho ratios in NAWM indicate an augmented glial cell density and decreased neuronal cell density. This altered tissue composition might be interpreted as adaptation to hypoperfusion and impaired vasoreactivity in NAWM of CADASIL patients. Our data might contribute to the general understanding of adaptive processes induced by hypoperfusion and chronic ischemia.",
keywords = "CADASIL, FMRI, Magnetic resonance spectroscopy, MRSI",
author = "Tamar Akhvlediani and Anke Henning and S{\'a}ndor, {Peter S.} and Peter Boesiger and Jung, {Hans H.}",
year = "2010",
month = "2",
day = "1",
doi = "10.1007/s00415-009-5281-5",
language = "English (US)",
volume = "257",
pages = "171--177",
journal = "Journal of Neurology",
issn = "0340-5354",
publisher = "D. Steinkopff-Verlag",
number = "2",

}

TY - JOUR

T1 - Adaptive metabolic changes in CADASIL white matter

AU - Akhvlediani, Tamar

AU - Henning, Anke

AU - Sándor, Peter S.

AU - Boesiger, Peter

AU - Jung, Hans H.

PY - 2010/2/1

Y1 - 2010/2/1

N2 - Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an important genetic cause of stroke, but pathogenic mechanisms and functional alterations remain poorly characterized. The purpose of this study was to investigate adaptive metabolic and functional changes in white matter hyperintensities and normal-appearing white matter in CADASIL patients using 1H-magnetic resonance spectroscopic imaging (MRSI). Eight CADASIL patients and eight matched healthy controls were studied. 1H-MRSI data were acquired on a 3T scanner using high-resolution multi-spin echo spectroscopic imaging (T E = 288 ms) and non-accelerated medium-resolution MRSI (T E = 35 ms). MRI of all CADASIL patients demonstrated characteristic white matter hyper-intensities (WMH) in the subcortical periventricular white matter. Cre/Cho, Glx/Cho and Glx/Cre ratios were significantly decreased in WMH compared to normal-appearing white matter (NAWM) in patients, while Glx/Cre and mI/Cho ratios in NAWM showed a significant increase compared to healthy controls. In severely affected patients derived spectra reflected a decrease of NAA concentrations inside WMH when compared to healthy white matter. Metabolic abnormalities in WMH of CADASIL patients are compatible with axonal loss due to chronic micro-infarctions. Increased Glx/Cre and mI/Cho ratios in NAWM indicate an augmented glial cell density and decreased neuronal cell density. This altered tissue composition might be interpreted as adaptation to hypoperfusion and impaired vasoreactivity in NAWM of CADASIL patients. Our data might contribute to the general understanding of adaptive processes induced by hypoperfusion and chronic ischemia.

AB - Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an important genetic cause of stroke, but pathogenic mechanisms and functional alterations remain poorly characterized. The purpose of this study was to investigate adaptive metabolic and functional changes in white matter hyperintensities and normal-appearing white matter in CADASIL patients using 1H-magnetic resonance spectroscopic imaging (MRSI). Eight CADASIL patients and eight matched healthy controls were studied. 1H-MRSI data were acquired on a 3T scanner using high-resolution multi-spin echo spectroscopic imaging (T E = 288 ms) and non-accelerated medium-resolution MRSI (T E = 35 ms). MRI of all CADASIL patients demonstrated characteristic white matter hyper-intensities (WMH) in the subcortical periventricular white matter. Cre/Cho, Glx/Cho and Glx/Cre ratios were significantly decreased in WMH compared to normal-appearing white matter (NAWM) in patients, while Glx/Cre and mI/Cho ratios in NAWM showed a significant increase compared to healthy controls. In severely affected patients derived spectra reflected a decrease of NAA concentrations inside WMH when compared to healthy white matter. Metabolic abnormalities in WMH of CADASIL patients are compatible with axonal loss due to chronic micro-infarctions. Increased Glx/Cre and mI/Cho ratios in NAWM indicate an augmented glial cell density and decreased neuronal cell density. This altered tissue composition might be interpreted as adaptation to hypoperfusion and impaired vasoreactivity in NAWM of CADASIL patients. Our data might contribute to the general understanding of adaptive processes induced by hypoperfusion and chronic ischemia.

KW - CADASIL

KW - FMRI

KW - Magnetic resonance spectroscopy

KW - MRSI

UR - http://www.scopus.com/inward/record.url?scp=77949271582&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77949271582&partnerID=8YFLogxK

U2 - 10.1007/s00415-009-5281-5

DO - 10.1007/s00415-009-5281-5

M3 - Article

C2 - 19690906

AN - SCOPUS:77949271582

VL - 257

SP - 171

EP - 177

JO - Journal of Neurology

JF - Journal of Neurology

SN - 0340-5354

IS - 2

ER -