Adaptive thermal therapy using planar ultrasound transducers with real-time MR temperature feedback: Demonstration in gel phantoms and ex-vivo tissues

Kee Tang, Vanessa Choy, Rajiv Chopra, Michael Bronskill

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

MRI-guided transurethral ultrasound therapy offers a minimally invasive approach for the treatment of localized prostate cancer. The main goal of this study was to evaluate active temperature feedback on a clinical 1.5T MR imager to control conformal thermal therapy. MR thermometry was performed during heating in both thermal gel phantoms and ex-vivo tissue with a single-element transurethral heating applicator. The applicator rotation rate and power were controlled based on MRI-temperature measurements. The influence of a cooling gradient (to simulate cooling of the rectum or urethra) was also investigated in gel phantoms. The 55°C isotherm generated during heating closely matched the targeted prostate shape, with an average distance error of 0.9 mm ± 0.4 mm in turkey breasts, 1.3 mm ± 0.5 mm in gel phantoms without rectal cooling and 1.4 mm ± 0.6 mm in gel phantoms with rectal cooling. Accurate, MRI-guided, active feedback has been successfully demonstrated experimentally and has the capability to adjust for unpredictable and varying tissue properties during the treatment.

Original languageEnglish (US)
Title of host publicationAIP Conference Proceedings
Pages300-306
Number of pages7
Volume911
DOIs
Publication statusPublished - 2007
Event6TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND - Oxford, United Kingdom
Duration: Aug 30 2007Sep 2 2007

Other

Other6TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND
CountryUnited Kingdom
CityOxford
Period8/30/079/2/07

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Keywords

  • Active feedback
  • MRI-guided
  • Prostate
  • Thermal therapy
  • Transurethral

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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