Addition of anti-neu antibody to local irradiation can improve tumor-bearing BALB/c mouse survival through immune-mediated mechanisms

Sae Gwang Park, Sun Young Ma, Hyunkeun Song, Jin Hee Park, Jae Hyeog Choi, Jin Ho Kim, Ki Hyang Kim, Sung Jae Park, Dong Hyen Park, Mi Seon Kang, Minjung Kwak, Yang Xin Fu, Inhak Choi, Heunglae Cho

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

This study investigated the therapeutic effects of combined local irradiation and anti-HER2/neu antibody in a mixed tumor mouse model comprised of a nonmetastatic neu-positive tumor and a metastatic neu-negative tumor. While local irradiation alone could control the primary tumor in a dose-dependent manner, it did not improve mouse survival. Combined treatment comprised of local irradiation and anti-neu antibody of tumor-bearing BALB/c mice significantly improved mouse survival (P < 0.5), even though the tumor growth was similar to that of the irradiated-alone group. The combined treatment significantly reduced metastatic tumor masses in the lung and increased immune cell infiltration in primary tumor tissues. However, immune deficient nude mice with tumors did not exhibit prolonged survival in response to the combined treatment. Collectively, these results show that combined local irradiation and anti-neu antibody can elicit an immune-mediated abscopal effect to extend survival. Although the mechanism for abscopal effects induced by the combined treatment of radiation and anti-HER2/neu antibody was not elucidated, to our knowledge this is the first published study to describe the abscopal effect induced by the combination of local irradiation and the anti-HER2/neu antibody.

Original languageEnglish (US)
Pages (from-to)271-278
Number of pages8
JournalRadiation Research
Volume183
Issue number3
DOIs
StatePublished - Jan 1 2015

Fingerprint

antibodies
mice
Anti-Idiotypic Antibodies
tumors
irradiation
Neoplasms
Antibodies
Therapeutic Uses
infiltration
Nude Mice
lungs
Radiation
dosage
Lung
radiation
Growth
cells

ASJC Scopus subject areas

  • Biophysics
  • Radiation
  • Radiology Nuclear Medicine and imaging

Cite this

Addition of anti-neu antibody to local irradiation can improve tumor-bearing BALB/c mouse survival through immune-mediated mechanisms. / Park, Sae Gwang; Ma, Sun Young; Song, Hyunkeun; Park, Jin Hee; Choi, Jae Hyeog; Kim, Jin Ho; Kim, Ki Hyang; Park, Sung Jae; Park, Dong Hyen; Kang, Mi Seon; Kwak, Minjung; Fu, Yang Xin; Choi, Inhak; Cho, Heunglae.

In: Radiation Research, Vol. 183, No. 3, 01.01.2015, p. 271-278.

Research output: Contribution to journalArticle

Park, SG, Ma, SY, Song, H, Park, JH, Choi, JH, Kim, JH, Kim, KH, Park, SJ, Park, DH, Kang, MS, Kwak, M, Fu, YX, Choi, I & Cho, H 2015, 'Addition of anti-neu antibody to local irradiation can improve tumor-bearing BALB/c mouse survival through immune-mediated mechanisms', Radiation Research, vol. 183, no. 3, pp. 271-278. https://doi.org/10.1667/RR13800.1
Park, Sae Gwang ; Ma, Sun Young ; Song, Hyunkeun ; Park, Jin Hee ; Choi, Jae Hyeog ; Kim, Jin Ho ; Kim, Ki Hyang ; Park, Sung Jae ; Park, Dong Hyen ; Kang, Mi Seon ; Kwak, Minjung ; Fu, Yang Xin ; Choi, Inhak ; Cho, Heunglae. / Addition of anti-neu antibody to local irradiation can improve tumor-bearing BALB/c mouse survival through immune-mediated mechanisms. In: Radiation Research. 2015 ; Vol. 183, No. 3. pp. 271-278.
@article{2526abaa250d4c918130ed2a2e2af317,
title = "Addition of anti-neu antibody to local irradiation can improve tumor-bearing BALB/c mouse survival through immune-mediated mechanisms",
abstract = "This study investigated the therapeutic effects of combined local irradiation and anti-HER2/neu antibody in a mixed tumor mouse model comprised of a nonmetastatic neu-positive tumor and a metastatic neu-negative tumor. While local irradiation alone could control the primary tumor in a dose-dependent manner, it did not improve mouse survival. Combined treatment comprised of local irradiation and anti-neu antibody of tumor-bearing BALB/c mice significantly improved mouse survival (P < 0.5), even though the tumor growth was similar to that of the irradiated-alone group. The combined treatment significantly reduced metastatic tumor masses in the lung and increased immune cell infiltration in primary tumor tissues. However, immune deficient nude mice with tumors did not exhibit prolonged survival in response to the combined treatment. Collectively, these results show that combined local irradiation and anti-neu antibody can elicit an immune-mediated abscopal effect to extend survival. Although the mechanism for abscopal effects induced by the combined treatment of radiation and anti-HER2/neu antibody was not elucidated, to our knowledge this is the first published study to describe the abscopal effect induced by the combination of local irradiation and the anti-HER2/neu antibody.",
author = "Park, {Sae Gwang} and Ma, {Sun Young} and Hyunkeun Song and Park, {Jin Hee} and Choi, {Jae Hyeog} and Kim, {Jin Ho} and Kim, {Ki Hyang} and Park, {Sung Jae} and Park, {Dong Hyen} and Kang, {Mi Seon} and Minjung Kwak and Fu, {Yang Xin} and Inhak Choi and Heunglae Cho",
year = "2015",
month = "1",
day = "1",
doi = "10.1667/RR13800.1",
language = "English (US)",
volume = "183",
pages = "271--278",
journal = "Radiation Research",
issn = "0033-7587",
publisher = "Radiation Research Society",
number = "3",

}

TY - JOUR

T1 - Addition of anti-neu antibody to local irradiation can improve tumor-bearing BALB/c mouse survival through immune-mediated mechanisms

AU - Park, Sae Gwang

AU - Ma, Sun Young

AU - Song, Hyunkeun

AU - Park, Jin Hee

AU - Choi, Jae Hyeog

AU - Kim, Jin Ho

AU - Kim, Ki Hyang

AU - Park, Sung Jae

AU - Park, Dong Hyen

AU - Kang, Mi Seon

AU - Kwak, Minjung

AU - Fu, Yang Xin

AU - Choi, Inhak

AU - Cho, Heunglae

PY - 2015/1/1

Y1 - 2015/1/1

N2 - This study investigated the therapeutic effects of combined local irradiation and anti-HER2/neu antibody in a mixed tumor mouse model comprised of a nonmetastatic neu-positive tumor and a metastatic neu-negative tumor. While local irradiation alone could control the primary tumor in a dose-dependent manner, it did not improve mouse survival. Combined treatment comprised of local irradiation and anti-neu antibody of tumor-bearing BALB/c mice significantly improved mouse survival (P < 0.5), even though the tumor growth was similar to that of the irradiated-alone group. The combined treatment significantly reduced metastatic tumor masses in the lung and increased immune cell infiltration in primary tumor tissues. However, immune deficient nude mice with tumors did not exhibit prolonged survival in response to the combined treatment. Collectively, these results show that combined local irradiation and anti-neu antibody can elicit an immune-mediated abscopal effect to extend survival. Although the mechanism for abscopal effects induced by the combined treatment of radiation and anti-HER2/neu antibody was not elucidated, to our knowledge this is the first published study to describe the abscopal effect induced by the combination of local irradiation and the anti-HER2/neu antibody.

AB - This study investigated the therapeutic effects of combined local irradiation and anti-HER2/neu antibody in a mixed tumor mouse model comprised of a nonmetastatic neu-positive tumor and a metastatic neu-negative tumor. While local irradiation alone could control the primary tumor in a dose-dependent manner, it did not improve mouse survival. Combined treatment comprised of local irradiation and anti-neu antibody of tumor-bearing BALB/c mice significantly improved mouse survival (P < 0.5), even though the tumor growth was similar to that of the irradiated-alone group. The combined treatment significantly reduced metastatic tumor masses in the lung and increased immune cell infiltration in primary tumor tissues. However, immune deficient nude mice with tumors did not exhibit prolonged survival in response to the combined treatment. Collectively, these results show that combined local irradiation and anti-neu antibody can elicit an immune-mediated abscopal effect to extend survival. Although the mechanism for abscopal effects induced by the combined treatment of radiation and anti-HER2/neu antibody was not elucidated, to our knowledge this is the first published study to describe the abscopal effect induced by the combination of local irradiation and the anti-HER2/neu antibody.

UR - http://www.scopus.com/inward/record.url?scp=84925153287&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84925153287&partnerID=8YFLogxK

U2 - 10.1667/RR13800.1

DO - 10.1667/RR13800.1

M3 - Article

C2 - 25706775

AN - SCOPUS:84925153287

VL - 183

SP - 271

EP - 278

JO - Radiation Research

JF - Radiation Research

SN - 0033-7587

IS - 3

ER -