Addition of vincristine and irinotecan to vincristine, dactinomycin, and cyclophosphamide does not improve outcome for intermediate-risk rhabdomyosarcoma: A report from the children’s oncology group

Douglas S. Hawkins, Yueh Yun Chi, James R. Anderson, Jing Tian, Carola A.S. Arndt, Lisa Bomgaars, Sarah S. Donaldson, Andrea Hayes-Jordan, Leo Mascarenhas, Mary Beth Mccarville, Jeannine S. Mccune, Geoff Mccowage, Lynn Million, Carol D. Morris, David M. Parham, David A. Rodeberg, Erin R. Rudzinski, Margarett Shnorhavorian, Sheri L. Spunt, Stephen X. SkapekLisa A. Teot, Suzanne Wolden, Torunn I. Yock, William H. Meyer

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Purpose Intermediate-risk rhabdomyosarcoma (RMS) includes patients with either nonmetastatic, unresected embryonal RMS (ERMS) with an unfavorable primary site or nonmetastatic alveolar RMS (ARMS). The primary aim of this study was to improve the outcome of patients with intermediate-risk RMS by substituting vincristine and irinotecan (VI) for half of vincristine, dactinomycin, and cyclophosphamide (VAC) courses. All patients received a lower dose of cyclophosphamide and earlier radiation therapy than in previous trials. Patients and Methods Patients were randomly assigned at study entry to either VAC (cumulative cyclophosphamide dose, 16.8 g/m2) or VAC/VI (cumulative cyclophosphamide dose, 8.4 g/m2) for 42 weeks of therapy. Radiation therapy started at week 4, with individualized local control plans permitted for patients younger than 24 months. The primary study end point was event-free survival (EFS). The study design had an 80% power (5% one-sided a-level) to detect an improved long-term EFS from 65% (with VAC) to 76% (with VAC/VI). Results A total of 448 eligible patients were enrolled in the study. At a median follow-up of 4.8 years, the 4-year EFS was 63% with VAC and 59% with VAC/VI (P = .51), and 4-year overall survival was 73% for VAC and 72% for VAC/VI (P = .80). Within the ARMS and ERMS subgroups, no difference in outcome by treatment arm was found. Severe hematologic toxicity was less common with VAC/VI therapy. Conclusion The addition of VI to VAC did not improve EFS or OS for patients with intermediate-risk RMS. VAC/VI had less hematologic toxicity and a lower cumulative cyclophosphamide dose, making VAC/VI an alternative standard therapy for intermediate-risk RMS.

Original languageEnglish (US)
Pages (from-to)2770-2777
Number of pages8
JournalJournal of Clinical Oncology
Volume36
Issue number27
DOIs
StatePublished - Sep 20 2018

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Hawkins, D. S., Chi, Y. Y., Anderson, J. R., Tian, J., Arndt, C. A. S., Bomgaars, L., Donaldson, S. S., Hayes-Jordan, A., Mascarenhas, L., Mccarville, M. B., Mccune, J. S., Mccowage, G., Million, L., Morris, C. D., Parham, D. M., Rodeberg, D. A., Rudzinski, E. R., Shnorhavorian, M., Spunt, S. L., ... Meyer, W. H. (2018). Addition of vincristine and irinotecan to vincristine, dactinomycin, and cyclophosphamide does not improve outcome for intermediate-risk rhabdomyosarcoma: A report from the children’s oncology group. Journal of Clinical Oncology, 36(27), 2770-2777. https://doi.org/10.1200/JCO.2018.77.9694