Adenocarcinoma of the prostate with Gleason pattern 5 on core biopsy: Frequency of diagnosis, morphologic subpatterns, and relation to pattern distribution based on the modified Gleason grading system

Rajal B. Shah, Yousef Tadros

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Accurate recognition of Gleason pattern 5 (GP5) prostate adenocarcinoma (PCa) on core biopsy (NBX) is critical because it is associated with disease progression and the worst clinical outcome. We evaluated 1557 consecutive and prospectively collected NBXs to determine the frequency of diagnosis, morphologic subpatterns, and their relation to the amount and pattern distribution of GP5 PCa based on the 2005 modified Gleason grading system. Tertiary GP5 was upgraded to a secondary pattern to derive the final Gleason score. GP5 accounted for 6% of all NBXs and 14% of PCa cases. GP5 PCas were associated with high-risk preoperative clinical and biopsy characteristics, regardless of the amount of GP5. Most patients (85%) with % GP5 greater than 5% of PCa had the final Gleason score of 9 to 10, compared with % GP5 of 5% or less of PCa (P <.0001). The morphologic subpatterns of GP5 PCas were as follows: infiltrating cords (96%), single cells (76%), solid sheets (29%), and comedocarcinoma (2%). Infiltrating cords and single-cell patterns frequently coexisted (76%). The GP5 was distributed in a tertiary (66%), followed by secondary (32%) and primary (2%) components of PCa. Infiltrating cords and single cells were the 2 most frequently encountered patterns, specifically when GP5 involved 5% or less of PCa and represented secondary or tertiary component of PCa. GP5 PCa is a relatively frequent presentation in the contemporary NBX practice. Because of its important prognostic and therapeutic implications, pathologists must be aware of its varied morphologic presentations and to the fact that most cases with GP5 represent a tertiary component of PCa.

Original languageEnglish (US)
Pages (from-to)2263-2269
Number of pages7
JournalHuman Pathology
Volume45
Issue number11
DOIs
StatePublished - Nov 1 2014
Externally publishedYes

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Neoplasm Grading
Prostate
Adenocarcinoma
Biopsy
Disease Progression

Keywords

  • Gleason pattern 5
  • Gleason pattern 5 morphologic subpatterns
  • Gleason score
  • Modified Gleason grading system
  • Prostate cancer
  • Prostate needle biopsy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

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title = "Adenocarcinoma of the prostate with Gleason pattern 5 on core biopsy: Frequency of diagnosis, morphologic subpatterns, and relation to pattern distribution based on the modified Gleason grading system",
abstract = "Accurate recognition of Gleason pattern 5 (GP5) prostate adenocarcinoma (PCa) on core biopsy (NBX) is critical because it is associated with disease progression and the worst clinical outcome. We evaluated 1557 consecutive and prospectively collected NBXs to determine the frequency of diagnosis, morphologic subpatterns, and their relation to the amount and pattern distribution of GP5 PCa based on the 2005 modified Gleason grading system. Tertiary GP5 was upgraded to a secondary pattern to derive the final Gleason score. GP5 accounted for 6{\%} of all NBXs and 14{\%} of PCa cases. GP5 PCas were associated with high-risk preoperative clinical and biopsy characteristics, regardless of the amount of GP5. Most patients (85{\%}) with {\%} GP5 greater than 5{\%} of PCa had the final Gleason score of 9 to 10, compared with {\%} GP5 of 5{\%} or less of PCa (P <.0001). The morphologic subpatterns of GP5 PCas were as follows: infiltrating cords (96{\%}), single cells (76{\%}), solid sheets (29{\%}), and comedocarcinoma (2{\%}). Infiltrating cords and single-cell patterns frequently coexisted (76{\%}). The GP5 was distributed in a tertiary (66{\%}), followed by secondary (32{\%}) and primary (2{\%}) components of PCa. Infiltrating cords and single cells were the 2 most frequently encountered patterns, specifically when GP5 involved 5{\%} or less of PCa and represented secondary or tertiary component of PCa. GP5 PCa is a relatively frequent presentation in the contemporary NBX practice. Because of its important prognostic and therapeutic implications, pathologists must be aware of its varied morphologic presentations and to the fact that most cases with GP5 represent a tertiary component of PCa.",
keywords = "Gleason pattern 5, Gleason pattern 5 morphologic subpatterns, Gleason score, Modified Gleason grading system, Prostate cancer, Prostate needle biopsy",
author = "Shah, {Rajal B.} and Yousef Tadros",
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T1 - Adenocarcinoma of the prostate with Gleason pattern 5 on core biopsy

T2 - Frequency of diagnosis, morphologic subpatterns, and relation to pattern distribution based on the modified Gleason grading system

AU - Shah, Rajal B.

AU - Tadros, Yousef

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Accurate recognition of Gleason pattern 5 (GP5) prostate adenocarcinoma (PCa) on core biopsy (NBX) is critical because it is associated with disease progression and the worst clinical outcome. We evaluated 1557 consecutive and prospectively collected NBXs to determine the frequency of diagnosis, morphologic subpatterns, and their relation to the amount and pattern distribution of GP5 PCa based on the 2005 modified Gleason grading system. Tertiary GP5 was upgraded to a secondary pattern to derive the final Gleason score. GP5 accounted for 6% of all NBXs and 14% of PCa cases. GP5 PCas were associated with high-risk preoperative clinical and biopsy characteristics, regardless of the amount of GP5. Most patients (85%) with % GP5 greater than 5% of PCa had the final Gleason score of 9 to 10, compared with % GP5 of 5% or less of PCa (P <.0001). The morphologic subpatterns of GP5 PCas were as follows: infiltrating cords (96%), single cells (76%), solid sheets (29%), and comedocarcinoma (2%). Infiltrating cords and single-cell patterns frequently coexisted (76%). The GP5 was distributed in a tertiary (66%), followed by secondary (32%) and primary (2%) components of PCa. Infiltrating cords and single cells were the 2 most frequently encountered patterns, specifically when GP5 involved 5% or less of PCa and represented secondary or tertiary component of PCa. GP5 PCa is a relatively frequent presentation in the contemporary NBX practice. Because of its important prognostic and therapeutic implications, pathologists must be aware of its varied morphologic presentations and to the fact that most cases with GP5 represent a tertiary component of PCa.

AB - Accurate recognition of Gleason pattern 5 (GP5) prostate adenocarcinoma (PCa) on core biopsy (NBX) is critical because it is associated with disease progression and the worst clinical outcome. We evaluated 1557 consecutive and prospectively collected NBXs to determine the frequency of diagnosis, morphologic subpatterns, and their relation to the amount and pattern distribution of GP5 PCa based on the 2005 modified Gleason grading system. Tertiary GP5 was upgraded to a secondary pattern to derive the final Gleason score. GP5 accounted for 6% of all NBXs and 14% of PCa cases. GP5 PCas were associated with high-risk preoperative clinical and biopsy characteristics, regardless of the amount of GP5. Most patients (85%) with % GP5 greater than 5% of PCa had the final Gleason score of 9 to 10, compared with % GP5 of 5% or less of PCa (P <.0001). The morphologic subpatterns of GP5 PCas were as follows: infiltrating cords (96%), single cells (76%), solid sheets (29%), and comedocarcinoma (2%). Infiltrating cords and single-cell patterns frequently coexisted (76%). The GP5 was distributed in a tertiary (66%), followed by secondary (32%) and primary (2%) components of PCa. Infiltrating cords and single cells were the 2 most frequently encountered patterns, specifically when GP5 involved 5% or less of PCa and represented secondary or tertiary component of PCa. GP5 PCa is a relatively frequent presentation in the contemporary NBX practice. Because of its important prognostic and therapeutic implications, pathologists must be aware of its varied morphologic presentations and to the fact that most cases with GP5 represent a tertiary component of PCa.

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KW - Modified Gleason grading system

KW - Prostate cancer

KW - Prostate needle biopsy

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