Adenosine: Front and center in linking nutrition and metabolism to neuronal activity

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Many individuals with epilepsy benefit from consuming a ketogenic diet, which is similar to the more commonly known Atkins diet. The underlying molecular reason for this has not been determined. However, in this issue of the JCI, Masino et al. have elucidated the mechanism responsible for the antiepileptic effects of the ketogenic diet in mice. The diet is shown to decrease expression of the enzyme adenosine kinase (Adk), which is responsible for clearing the endogenous antiepileptic agent adenosine (Ado) from the extracellular CNS space. Decreased expression of Adk results in increased extracellular Ado, activation of inhibitory Ado A1 receptors, and decreased seizure generation, the desired therapeutic effect. The authors' work serves to emphasize the importance of controlling Adk expression, not only as the mechanism of action of the ketogenic diet, but also as a potential target of future therapies.

Original languageEnglish (US)
Pages (from-to)2548-2550
Number of pages3
JournalJournal of Clinical Investigation
Volume121
Issue number7
DOIs
StatePublished - Jul 2011

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Adenosine Kinase
Ketogenic Diet
Adenosine
Anticonvulsants
Carbohydrate-Restricted Diet
Adenosine A1 Receptors
Extracellular Space
Therapeutic Uses
Epilepsy
Seizures
Diet
Enzymes
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Adenosine : Front and center in linking nutrition and metabolism to neuronal activity. / Greene, Robert W.

In: Journal of Clinical Investigation, Vol. 121, No. 7, 07.2011, p. 2548-2550.

Research output: Contribution to journalArticle

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