Adenosine reduces cortical neuronal injury induced by oxygen or glucose deprivation in vitro

Mark P. Goldberg, Hannelore Monyer, John H. Weiss, Dennis W. Choi

Research output: Contribution to journalArticle

106 Scopus citations

Abstract

The endogenous neuromodulatory purine, adenosine, substantially attenuated neuronal degeneration when added to dissociated cortical cell cultures acutely deprived of either oxygen or glucose. The protective effect of adenosine was concentration-dependent between 30 and 1000 μM (EC50 about 100 μM), and could be mimicked by the stable adenosine analogue N6-cyclohexyladenosine (10 μM). Unlike postsynaptic glutamate receptor antagonists, which also block these forms of neuronal injury, adenosine did not alter the neurotoxicity of exogenously applied glutamate.

Original languageEnglish (US)
Pages (from-to)323-327
Number of pages5
JournalNeuroscience Letters
Volume89
Issue number3
DOIs
StatePublished - Jul 8 1988

Keywords

  • Adenosine
  • Cell culture
  • Cerebral cortex
  • Cyclohexyladenosine
  • Glutamate
  • Hypoglycemia
  • Hypoxia

ASJC Scopus subject areas

  • Neuroscience(all)

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