Adenosine triphosphate release and purinergic regulation of cholangiocyte transport

Andrew P. Feranchak, J. Gregory Fitz

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The discovery of purinergic receptors on almost every cell type studied to date suggests that purinergic signaling is a fundamental process regulating cell and organ level functions. Purinergic receptors have been found on all principal liver cell types, including liver parenchymal cells, or hepatocytes, and biliary epithelial cells, or cholangiocytes. Both hepatocytes and cholangiocytes are capable of the regulated release of adenosine triphosphate (ATP), and both cell types express a range of purinergic receptors to mediate cellular processes. The role of extracellular nucleotides in liver function is presently being elucidated. Extracellular ATP, in addition to autocrine regulation of liver cell volume, has recently been shown to play an important role in paracrine signaling to coordinate specific hepatocyte and cholangiocyte cellular responses. The findings that (1) cholangiocytes are capable of the regulated release of ATP into bile, (2) ATP is present in bile in concentrations capable of stimulating purinergic receptors, and (3) P2 receptor stimulation results in brisk Cl- channel activation and fluid secretion suggest an important role of extracellular ATP in the regulation of bile formation. This article highlights important developments in our understanding of the role of purinergic signaling in cholangiocyte transport and bile formation.

Original languageEnglish (US)
Pages (from-to)251-262
Number of pages12
JournalSeminars in Liver Disease
Volume22
Issue number3
DOIs
StatePublished - Aug 2002

Fingerprint

Purinergic Receptors
Bile
Adenosine Triphosphate
Hepatocytes
Liver
Paracrine Communication
Purinergic P2 Receptors
Fluids and Secretions
Cell Size
Nucleotides
Epithelial Cells

Keywords

  • Bile
  • Biliary epithelium
  • CFTR
  • Cl- channel
  • Nucleotides
  • P2 receptor
  • Purinergic signaling

ASJC Scopus subject areas

  • Hepatology

Cite this

Adenosine triphosphate release and purinergic regulation of cholangiocyte transport. / Feranchak, Andrew P.; Fitz, J. Gregory.

In: Seminars in Liver Disease, Vol. 22, No. 3, 08.2002, p. 251-262.

Research output: Contribution to journalArticle

@article{c97a2eae82774b2bb8f43d9d513f2e26,
title = "Adenosine triphosphate release and purinergic regulation of cholangiocyte transport",
abstract = "The discovery of purinergic receptors on almost every cell type studied to date suggests that purinergic signaling is a fundamental process regulating cell and organ level functions. Purinergic receptors have been found on all principal liver cell types, including liver parenchymal cells, or hepatocytes, and biliary epithelial cells, or cholangiocytes. Both hepatocytes and cholangiocytes are capable of the regulated release of adenosine triphosphate (ATP), and both cell types express a range of purinergic receptors to mediate cellular processes. The role of extracellular nucleotides in liver function is presently being elucidated. Extracellular ATP, in addition to autocrine regulation of liver cell volume, has recently been shown to play an important role in paracrine signaling to coordinate specific hepatocyte and cholangiocyte cellular responses. The findings that (1) cholangiocytes are capable of the regulated release of ATP into bile, (2) ATP is present in bile in concentrations capable of stimulating purinergic receptors, and (3) P2 receptor stimulation results in brisk Cl- channel activation and fluid secretion suggest an important role of extracellular ATP in the regulation of bile formation. This article highlights important developments in our understanding of the role of purinergic signaling in cholangiocyte transport and bile formation.",
keywords = "Bile, Biliary epithelium, CFTR, Cl- channel, Nucleotides, P2 receptor, Purinergic signaling",
author = "Feranchak, {Andrew P.} and Fitz, {J. Gregory}",
year = "2002",
month = "8",
doi = "10.1055/s-2002-34503",
language = "English (US)",
volume = "22",
pages = "251--262",
journal = "Seminars in Liver Disease",
issn = "0272-8087",
publisher = "Thieme Medical Publishers",
number = "3",

}

TY - JOUR

T1 - Adenosine triphosphate release and purinergic regulation of cholangiocyte transport

AU - Feranchak, Andrew P.

AU - Fitz, J. Gregory

PY - 2002/8

Y1 - 2002/8

N2 - The discovery of purinergic receptors on almost every cell type studied to date suggests that purinergic signaling is a fundamental process regulating cell and organ level functions. Purinergic receptors have been found on all principal liver cell types, including liver parenchymal cells, or hepatocytes, and biliary epithelial cells, or cholangiocytes. Both hepatocytes and cholangiocytes are capable of the regulated release of adenosine triphosphate (ATP), and both cell types express a range of purinergic receptors to mediate cellular processes. The role of extracellular nucleotides in liver function is presently being elucidated. Extracellular ATP, in addition to autocrine regulation of liver cell volume, has recently been shown to play an important role in paracrine signaling to coordinate specific hepatocyte and cholangiocyte cellular responses. The findings that (1) cholangiocytes are capable of the regulated release of ATP into bile, (2) ATP is present in bile in concentrations capable of stimulating purinergic receptors, and (3) P2 receptor stimulation results in brisk Cl- channel activation and fluid secretion suggest an important role of extracellular ATP in the regulation of bile formation. This article highlights important developments in our understanding of the role of purinergic signaling in cholangiocyte transport and bile formation.

AB - The discovery of purinergic receptors on almost every cell type studied to date suggests that purinergic signaling is a fundamental process regulating cell and organ level functions. Purinergic receptors have been found on all principal liver cell types, including liver parenchymal cells, or hepatocytes, and biliary epithelial cells, or cholangiocytes. Both hepatocytes and cholangiocytes are capable of the regulated release of adenosine triphosphate (ATP), and both cell types express a range of purinergic receptors to mediate cellular processes. The role of extracellular nucleotides in liver function is presently being elucidated. Extracellular ATP, in addition to autocrine regulation of liver cell volume, has recently been shown to play an important role in paracrine signaling to coordinate specific hepatocyte and cholangiocyte cellular responses. The findings that (1) cholangiocytes are capable of the regulated release of ATP into bile, (2) ATP is present in bile in concentrations capable of stimulating purinergic receptors, and (3) P2 receptor stimulation results in brisk Cl- channel activation and fluid secretion suggest an important role of extracellular ATP in the regulation of bile formation. This article highlights important developments in our understanding of the role of purinergic signaling in cholangiocyte transport and bile formation.

KW - Bile

KW - Biliary epithelium

KW - CFTR

KW - Cl- channel

KW - Nucleotides

KW - P2 receptor

KW - Purinergic signaling

UR - http://www.scopus.com/inward/record.url?scp=0036697257&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036697257&partnerID=8YFLogxK

U2 - 10.1055/s-2002-34503

DO - 10.1055/s-2002-34503

M3 - Article

C2 - 12360419

AN - SCOPUS:0036697257

VL - 22

SP - 251

EP - 262

JO - Seminars in Liver Disease

JF - Seminars in Liver Disease

SN - 0272-8087

IS - 3

ER -