TY - JOUR
T1 - Adenylate cyclase activation shifts the phase of a circadian pacemaker
AU - Eskin, Arnold
AU - Takahashi, Joseph S.
PY - 1983/1/1
Y1 - 1983/1/1
N2 - Forskolin, a highly specific activator of adenylate cyclase, produced both delay and advance phase shifts of the circadian rhythm recorded from the isolated eye of the marine mollusk Aplysia. The phase dependence of the response to forskolin was identical to that with serotonin, which also stimulates adenylate cyclase in the eye. The ability of agents to activate adenylate cyclase in homogenates was correlated with their ability to shift the phase of the circadian oscillator. These results along with earlier findings show that adenosine 3' ,5'-monophosphate mediates the effect of serotonin on the rhythm and regulates the phase of the circadian pacemaker in the eye of Aplysia.
AB - Forskolin, a highly specific activator of adenylate cyclase, produced both delay and advance phase shifts of the circadian rhythm recorded from the isolated eye of the marine mollusk Aplysia. The phase dependence of the response to forskolin was identical to that with serotonin, which also stimulates adenylate cyclase in the eye. The ability of agents to activate adenylate cyclase in homogenates was correlated with their ability to shift the phase of the circadian oscillator. These results along with earlier findings show that adenosine 3' ,5'-monophosphate mediates the effect of serotonin on the rhythm and regulates the phase of the circadian pacemaker in the eye of Aplysia.
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U2 - 10.1126/science.6298939
DO - 10.1126/science.6298939
M3 - Article
C2 - 6298939
AN - SCOPUS:0020679219
SN - 0036-8075
VL - 220
SP - 82
EP - 84
JO - Science
JF - Science
IS - 4592
ER -