Adenylate cyclase activation shifts the phase of a circadian pacemaker

Arnold Eskin, Joseph S. Takahashi

Research output: Contribution to journalArticle

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Abstract

Forskolin, a highly specific activator of adenylate cyclase, produced both delay and advance phase shifts of the circadian rhythm recorded from the isolated eye of the marine mollusk Aplysia. The phase dependence of the response to forskolin was identical to that with serotonin, which also stimulates adenylate cyclase in the eye. The ability of agents to activate adenylate cyclase in homogenates was correlated with their ability to shift the phase of the circadian oscillator. These results along with earlier findings show that adenosine 3' ,5'-monophosphate mediates the effect of serotonin on the rhythm and regulates the phase of the circadian pacemaker in the eye of Aplysia.

Original languageEnglish (US)
Pages (from-to)82-84
Number of pages3
JournalScience
Volume220
Issue number4592
DOIs
StatePublished - Jan 1 1983

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