Adenylosuccinate lyase hydroxylation contributes to triple negative breast cancer via the activation of cMYC

Giada Zurlo, Qing Zhang

Research output: Contribution to journalArticlepeer-review

Abstract

Hydroxylation is a post-translational modification affecting protein stability, activity or interactome. We identified adenylosuccinate lyase (ADSL) as a novel hydroxylation substrate in triple negative breast cancer. Hydroxylation affects ADSL enzymatic activity and, therefore, adenosine levels. Adenosine, in turn, favors the translation of cMYC, triggering its oncogenic downstream cascade.

Original languageEnglish (US)
Article number1707045
JournalMolecular and Cellular Oncology
Volume7
Issue number2
DOIs
StatePublished - Mar 3 2020

Keywords

  • adenosine
  • ADSL
  • cMYC
  • hydroxylation
  • triple negative breast cancer

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research

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