Adequacy of a single stone risk analysis in the medical evaluation of urolithiasis

Charles Y C Pak, Roy Peterson, John R. Poindexter

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Purpose: We tested the hypothesis that a single 24-hour urine sample for stone risk analysis would be sufficient for the simplified medical evaluation of urolithiasis. Materials and Methods: We retrospectively analyzed stone risk profile data on 24-hour urine samples obtained during random and restricted diets in 225 patients with recurrent urolithiasis. Results: In 2 random samples we noted no significant difference in urinary calcium, oxalate, uric acid, citrate, pH, total volume, sodium, potassium, sulfate or phosphorus. For these risk factors there was a highly significant positive correlation in the 2 random samples (r ≥0.68, p < 0.0003) and the value of each was abnormal or normal in at least 81% of patients. Urinary magnesium and ammonium were significantly lower in random sample 2 than 1, the former by 4%. After calcium, sodium and oxalate dietary restriction mean urinary calcium and sodium plus or minus standard deviation decreased significantly by 25% from 251 ± 125 to 187 ± 98 mg. daily and by 38% from 183 ± 87 to 113 ± 57 mEq. daily, respectively. Other risk factors had a slight or no significant change. Correcting random urinary calcium for the excessive urinary excretion of sodium brought urinary calcium to 210 ± 108 mg. daily, similar to the value on the restricted diet. Conclusions: The reproducibility of urinary stone risk factors is satisfactory in repeat urine samples. A single stone risk analysis is sufficient for the simplified medical evaluation of urolithiasis.

Original languageEnglish (US)
Pages (from-to)378-381
Number of pages4
JournalJournal of Urology
Volume165
Issue number2
DOIs
StatePublished - 2001

Fingerprint

Urolithiasis
Calcium
Urine
Sodium
Diet
Oxalic Acid
Calcium Oxalate
Urinary Calculi
Uric Acid
Ammonium Compounds
Citric Acid
Phosphorus
Magnesium

Keywords

  • Kidney
  • Risk factors
  • Urinary calculi

ASJC Scopus subject areas

  • Urology

Cite this

Adequacy of a single stone risk analysis in the medical evaluation of urolithiasis. / Pak, Charles Y C; Peterson, Roy; Poindexter, John R.

In: Journal of Urology, Vol. 165, No. 2, 2001, p. 378-381.

Research output: Contribution to journalArticle

Pak, Charles Y C ; Peterson, Roy ; Poindexter, John R. / Adequacy of a single stone risk analysis in the medical evaluation of urolithiasis. In: Journal of Urology. 2001 ; Vol. 165, No. 2. pp. 378-381.
@article{d54ada7b26c84315a26f1d40b7f647c0,
title = "Adequacy of a single stone risk analysis in the medical evaluation of urolithiasis",
abstract = "Purpose: We tested the hypothesis that a single 24-hour urine sample for stone risk analysis would be sufficient for the simplified medical evaluation of urolithiasis. Materials and Methods: We retrospectively analyzed stone risk profile data on 24-hour urine samples obtained during random and restricted diets in 225 patients with recurrent urolithiasis. Results: In 2 random samples we noted no significant difference in urinary calcium, oxalate, uric acid, citrate, pH, total volume, sodium, potassium, sulfate or phosphorus. For these risk factors there was a highly significant positive correlation in the 2 random samples (r ≥0.68, p < 0.0003) and the value of each was abnormal or normal in at least 81{\%} of patients. Urinary magnesium and ammonium were significantly lower in random sample 2 than 1, the former by 4{\%}. After calcium, sodium and oxalate dietary restriction mean urinary calcium and sodium plus or minus standard deviation decreased significantly by 25{\%} from 251 ± 125 to 187 ± 98 mg. daily and by 38{\%} from 183 ± 87 to 113 ± 57 mEq. daily, respectively. Other risk factors had a slight or no significant change. Correcting random urinary calcium for the excessive urinary excretion of sodium brought urinary calcium to 210 ± 108 mg. daily, similar to the value on the restricted diet. Conclusions: The reproducibility of urinary stone risk factors is satisfactory in repeat urine samples. A single stone risk analysis is sufficient for the simplified medical evaluation of urolithiasis.",
keywords = "Kidney, Risk factors, Urinary calculi",
author = "Pak, {Charles Y C} and Roy Peterson and Poindexter, {John R.}",
year = "2001",
doi = "10.1097/00005392-200102000-00006",
language = "English (US)",
volume = "165",
pages = "378--381",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Adequacy of a single stone risk analysis in the medical evaluation of urolithiasis

AU - Pak, Charles Y C

AU - Peterson, Roy

AU - Poindexter, John R.

PY - 2001

Y1 - 2001

N2 - Purpose: We tested the hypothesis that a single 24-hour urine sample for stone risk analysis would be sufficient for the simplified medical evaluation of urolithiasis. Materials and Methods: We retrospectively analyzed stone risk profile data on 24-hour urine samples obtained during random and restricted diets in 225 patients with recurrent urolithiasis. Results: In 2 random samples we noted no significant difference in urinary calcium, oxalate, uric acid, citrate, pH, total volume, sodium, potassium, sulfate or phosphorus. For these risk factors there was a highly significant positive correlation in the 2 random samples (r ≥0.68, p < 0.0003) and the value of each was abnormal or normal in at least 81% of patients. Urinary magnesium and ammonium were significantly lower in random sample 2 than 1, the former by 4%. After calcium, sodium and oxalate dietary restriction mean urinary calcium and sodium plus or minus standard deviation decreased significantly by 25% from 251 ± 125 to 187 ± 98 mg. daily and by 38% from 183 ± 87 to 113 ± 57 mEq. daily, respectively. Other risk factors had a slight or no significant change. Correcting random urinary calcium for the excessive urinary excretion of sodium brought urinary calcium to 210 ± 108 mg. daily, similar to the value on the restricted diet. Conclusions: The reproducibility of urinary stone risk factors is satisfactory in repeat urine samples. A single stone risk analysis is sufficient for the simplified medical evaluation of urolithiasis.

AB - Purpose: We tested the hypothesis that a single 24-hour urine sample for stone risk analysis would be sufficient for the simplified medical evaluation of urolithiasis. Materials and Methods: We retrospectively analyzed stone risk profile data on 24-hour urine samples obtained during random and restricted diets in 225 patients with recurrent urolithiasis. Results: In 2 random samples we noted no significant difference in urinary calcium, oxalate, uric acid, citrate, pH, total volume, sodium, potassium, sulfate or phosphorus. For these risk factors there was a highly significant positive correlation in the 2 random samples (r ≥0.68, p < 0.0003) and the value of each was abnormal or normal in at least 81% of patients. Urinary magnesium and ammonium were significantly lower in random sample 2 than 1, the former by 4%. After calcium, sodium and oxalate dietary restriction mean urinary calcium and sodium plus or minus standard deviation decreased significantly by 25% from 251 ± 125 to 187 ± 98 mg. daily and by 38% from 183 ± 87 to 113 ± 57 mEq. daily, respectively. Other risk factors had a slight or no significant change. Correcting random urinary calcium for the excessive urinary excretion of sodium brought urinary calcium to 210 ± 108 mg. daily, similar to the value on the restricted diet. Conclusions: The reproducibility of urinary stone risk factors is satisfactory in repeat urine samples. A single stone risk analysis is sufficient for the simplified medical evaluation of urolithiasis.

KW - Kidney

KW - Risk factors

KW - Urinary calculi

UR - http://www.scopus.com/inward/record.url?scp=0035176621&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035176621&partnerID=8YFLogxK

U2 - 10.1097/00005392-200102000-00006

DO - 10.1097/00005392-200102000-00006

M3 - Article

C2 - 11176377

AN - SCOPUS:0035176621

VL - 165

SP - 378

EP - 381

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 2

ER -