Adherence of Helicobacter pylori to areas of incomplete intestinal metaplasia in the gastric mucosa

R. M. Genta, I. E. Gurer, D. Y. Graham, B. Krishnan, A. M. Segura, O. Gutierrez, J. G. Kim, Jr Burchette J.L.

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Background and Aims: Helicobacter pylori is not usually found in areas of intestinal metaplasia. Thus, the development of intestinal metaplasia has been viewed as a mechanism by which the stomach eliminates H. pylori. The aim of this study was to evaluate the frequency of H. pylori adherence to intestinal metaplasia in different populations. Methods: Mapped gastric biopsy specimens from 378 H. pylori-positive subjects from various geographical regions were examined. Intestinal metaplasia was typed by staining with periodic acid-Schiff/alcian blue and high-iron diamine/alcian blue. Results: In 32 patients, H. pylori was found in intimate contact with intestinal metaplasia. This was documented by electron microscopy. All areas of intestinal metaplasia showing adherence contained sulfomucins and had no brush border. Posttreatment biopsy specimens from 4 patients whose infection was not cured showed persistence of H. pylori in intestinal metaplasia. Conclusions: These patients may have a strain of H. pylori with unusual adhesion characteristics, or their type of intestinal metaplasia may have biochemical properties that make it hospitable for H. pylori. The exclusive association of H. pylori adherence with incomplete intestinal metaplasia (a putative precursor of carcinoma) and its greater frequency in Koreans (a population at risk for gastric cancer) suggest that this phenomenon may play a role in the hypothetical sequence metaplasia > dysplasia > carcinoma.

Original languageEnglish (US)
Pages (from-to)1206-1211
Number of pages6
JournalGastroenterology
Volume111
Issue number5
DOIs
StatePublished - 1996

Fingerprint

Metaplasia
Gastric Mucosa
Helicobacter pylori
Stomach
Carcinoma
Biopsy
Alcian Blue
Periodic Acid
Microvilli
Stomach Neoplasms
Electron Microscopy
Staining and Labeling

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Genta, R. M., Gurer, I. E., Graham, D. Y., Krishnan, B., Segura, A. M., Gutierrez, O., ... Burchette J.L., J. (1996). Adherence of Helicobacter pylori to areas of incomplete intestinal metaplasia in the gastric mucosa. Gastroenterology, 111(5), 1206-1211. https://doi.org/10.1053/gast.1996.v111.pm8898634

Adherence of Helicobacter pylori to areas of incomplete intestinal metaplasia in the gastric mucosa. / Genta, R. M.; Gurer, I. E.; Graham, D. Y.; Krishnan, B.; Segura, A. M.; Gutierrez, O.; Kim, J. G.; Burchette J.L., Jr.

In: Gastroenterology, Vol. 111, No. 5, 1996, p. 1206-1211.

Research output: Contribution to journalArticle

Genta, RM, Gurer, IE, Graham, DY, Krishnan, B, Segura, AM, Gutierrez, O, Kim, JG & Burchette J.L., J 1996, 'Adherence of Helicobacter pylori to areas of incomplete intestinal metaplasia in the gastric mucosa', Gastroenterology, vol. 111, no. 5, pp. 1206-1211. https://doi.org/10.1053/gast.1996.v111.pm8898634
Genta, R. M. ; Gurer, I. E. ; Graham, D. Y. ; Krishnan, B. ; Segura, A. M. ; Gutierrez, O. ; Kim, J. G. ; Burchette J.L., Jr. / Adherence of Helicobacter pylori to areas of incomplete intestinal metaplasia in the gastric mucosa. In: Gastroenterology. 1996 ; Vol. 111, No. 5. pp. 1206-1211.
@article{c5e4321168c248b0b1a3d82226254abf,
title = "Adherence of Helicobacter pylori to areas of incomplete intestinal metaplasia in the gastric mucosa",
abstract = "Background and Aims: Helicobacter pylori is not usually found in areas of intestinal metaplasia. Thus, the development of intestinal metaplasia has been viewed as a mechanism by which the stomach eliminates H. pylori. The aim of this study was to evaluate the frequency of H. pylori adherence to intestinal metaplasia in different populations. Methods: Mapped gastric biopsy specimens from 378 H. pylori-positive subjects from various geographical regions were examined. Intestinal metaplasia was typed by staining with periodic acid-Schiff/alcian blue and high-iron diamine/alcian blue. Results: In 32 patients, H. pylori was found in intimate contact with intestinal metaplasia. This was documented by electron microscopy. All areas of intestinal metaplasia showing adherence contained sulfomucins and had no brush border. Posttreatment biopsy specimens from 4 patients whose infection was not cured showed persistence of H. pylori in intestinal metaplasia. Conclusions: These patients may have a strain of H. pylori with unusual adhesion characteristics, or their type of intestinal metaplasia may have biochemical properties that make it hospitable for H. pylori. The exclusive association of H. pylori adherence with incomplete intestinal metaplasia (a putative precursor of carcinoma) and its greater frequency in Koreans (a population at risk for gastric cancer) suggest that this phenomenon may play a role in the hypothetical sequence metaplasia > dysplasia > carcinoma.",
author = "Genta, {R. M.} and Gurer, {I. E.} and Graham, {D. Y.} and B. Krishnan and Segura, {A. M.} and O. Gutierrez and Kim, {J. G.} and {Burchette J.L.}, Jr",
year = "1996",
doi = "10.1053/gast.1996.v111.pm8898634",
language = "English (US)",
volume = "111",
pages = "1206--1211",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "5",

}

TY - JOUR

T1 - Adherence of Helicobacter pylori to areas of incomplete intestinal metaplasia in the gastric mucosa

AU - Genta, R. M.

AU - Gurer, I. E.

AU - Graham, D. Y.

AU - Krishnan, B.

AU - Segura, A. M.

AU - Gutierrez, O.

AU - Kim, J. G.

AU - Burchette J.L., Jr

PY - 1996

Y1 - 1996

N2 - Background and Aims: Helicobacter pylori is not usually found in areas of intestinal metaplasia. Thus, the development of intestinal metaplasia has been viewed as a mechanism by which the stomach eliminates H. pylori. The aim of this study was to evaluate the frequency of H. pylori adherence to intestinal metaplasia in different populations. Methods: Mapped gastric biopsy specimens from 378 H. pylori-positive subjects from various geographical regions were examined. Intestinal metaplasia was typed by staining with periodic acid-Schiff/alcian blue and high-iron diamine/alcian blue. Results: In 32 patients, H. pylori was found in intimate contact with intestinal metaplasia. This was documented by electron microscopy. All areas of intestinal metaplasia showing adherence contained sulfomucins and had no brush border. Posttreatment biopsy specimens from 4 patients whose infection was not cured showed persistence of H. pylori in intestinal metaplasia. Conclusions: These patients may have a strain of H. pylori with unusual adhesion characteristics, or their type of intestinal metaplasia may have biochemical properties that make it hospitable for H. pylori. The exclusive association of H. pylori adherence with incomplete intestinal metaplasia (a putative precursor of carcinoma) and its greater frequency in Koreans (a population at risk for gastric cancer) suggest that this phenomenon may play a role in the hypothetical sequence metaplasia > dysplasia > carcinoma.

AB - Background and Aims: Helicobacter pylori is not usually found in areas of intestinal metaplasia. Thus, the development of intestinal metaplasia has been viewed as a mechanism by which the stomach eliminates H. pylori. The aim of this study was to evaluate the frequency of H. pylori adherence to intestinal metaplasia in different populations. Methods: Mapped gastric biopsy specimens from 378 H. pylori-positive subjects from various geographical regions were examined. Intestinal metaplasia was typed by staining with periodic acid-Schiff/alcian blue and high-iron diamine/alcian blue. Results: In 32 patients, H. pylori was found in intimate contact with intestinal metaplasia. This was documented by electron microscopy. All areas of intestinal metaplasia showing adherence contained sulfomucins and had no brush border. Posttreatment biopsy specimens from 4 patients whose infection was not cured showed persistence of H. pylori in intestinal metaplasia. Conclusions: These patients may have a strain of H. pylori with unusual adhesion characteristics, or their type of intestinal metaplasia may have biochemical properties that make it hospitable for H. pylori. The exclusive association of H. pylori adherence with incomplete intestinal metaplasia (a putative precursor of carcinoma) and its greater frequency in Koreans (a population at risk for gastric cancer) suggest that this phenomenon may play a role in the hypothetical sequence metaplasia > dysplasia > carcinoma.

UR - http://www.scopus.com/inward/record.url?scp=0029809550&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029809550&partnerID=8YFLogxK

U2 - 10.1053/gast.1996.v111.pm8898634

DO - 10.1053/gast.1996.v111.pm8898634

M3 - Article

C2 - 8898634

AN - SCOPUS:0029809550

VL - 111

SP - 1206

EP - 1211

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 5

ER -