Adherence to Biopsy Guidelines for Barrett's Esophagus Surveillance in the Community Setting in the United States

Julian A. Abrams, Robert C. Kapel, Guy M. Lindberg, Mohammad H. Saboorian, Robert M. Genta, Alfred I. Neugut, Charles J. Lightdale

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Abstract

Background & Aims: Current surveillance guidelines for Barrett's esophagus (BE) recommend extensive biopsies to minimize sampling error. Biopsy practice patterns for BE surveillance in the community have not been well-described. We used a national community-based pathology database to analyze adherence to guidelines and to determine whether adherence was associated with dysplasia detection. Methods: We identified 10,958 cases of established BE in the Caris Diagnostics pathology database from January 2002-April 2007. Demographic, pathologic, and endoscopic data were recorded. Dysplasia was categorized as low grade, high grade, or adenocarcinoma. Adherence was defined as ≥4 esophageal biopsies per 2 cm BE or a ratio ≥2.0. Generalized estimating equation multivariable analysis was performed to assess factors associated with adherence, adjusted for clustering by individual gastroenterologist. Results: A total of 2245 BE surveillance cases were identified with linked endoscopy reports that recorded BE length and could be assessed for adherence. Adherence to guidelines was seen in 51.2% of cases. In multivariable analysis, longer segment BE was associated with significantly reduced adherence (3-5 cm, odds ratio [OR] 0.14, 95% confidence interval [CI] 0.10-0.19; 6-8 cm, OR 0.06, 95% CI 0.03-0.09; ≥9 cm, OR 0.03, 95% CI 0.01-0.07). Stratified by BE length, nonadherence was associated with significantly decreased dysplasia detection (summary OR 0.53, 95% CI 0.35-0.82). Conclusions: Adherence to BE biopsy guidelines in the community is low, and nonadherence is associated with significantly decreased dysplasia detection. Future studies should identify factors underlying nonadherence as well as mechanisms to increase adherence to guidelines to improve early detection of dysplasia.

Original languageEnglish (US)
Pages (from-to)736-742
Number of pages7
JournalClinical Gastroenterology and Hepatology
Volume7
Issue number7
DOIs
StatePublished - Jul 2009

Fingerprint

Barrett Esophagus
Guidelines
Biopsy
Guideline Adherence
Odds Ratio
Confidence Intervals
Databases
Pathology
Selection Bias
Endoscopy
Cluster Analysis
Adenocarcinoma
Demography

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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Adherence to Biopsy Guidelines for Barrett's Esophagus Surveillance in the Community Setting in the United States. / Abrams, Julian A.; Kapel, Robert C.; Lindberg, Guy M.; Saboorian, Mohammad H.; Genta, Robert M.; Neugut, Alfred I.; Lightdale, Charles J.

In: Clinical Gastroenterology and Hepatology, Vol. 7, No. 7, 07.2009, p. 736-742.

Research output: Contribution to journalArticle

Abrams, Julian A. ; Kapel, Robert C. ; Lindberg, Guy M. ; Saboorian, Mohammad H. ; Genta, Robert M. ; Neugut, Alfred I. ; Lightdale, Charles J. / Adherence to Biopsy Guidelines for Barrett's Esophagus Surveillance in the Community Setting in the United States. In: Clinical Gastroenterology and Hepatology. 2009 ; Vol. 7, No. 7. pp. 736-742.
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abstract = "Background & Aims: Current surveillance guidelines for Barrett's esophagus (BE) recommend extensive biopsies to minimize sampling error. Biopsy practice patterns for BE surveillance in the community have not been well-described. We used a national community-based pathology database to analyze adherence to guidelines and to determine whether adherence was associated with dysplasia detection. Methods: We identified 10,958 cases of established BE in the Caris Diagnostics pathology database from January 2002-April 2007. Demographic, pathologic, and endoscopic data were recorded. Dysplasia was categorized as low grade, high grade, or adenocarcinoma. Adherence was defined as ≥4 esophageal biopsies per 2 cm BE or a ratio ≥2.0. Generalized estimating equation multivariable analysis was performed to assess factors associated with adherence, adjusted for clustering by individual gastroenterologist. Results: A total of 2245 BE surveillance cases were identified with linked endoscopy reports that recorded BE length and could be assessed for adherence. Adherence to guidelines was seen in 51.2{\%} of cases. In multivariable analysis, longer segment BE was associated with significantly reduced adherence (3-5 cm, odds ratio [OR] 0.14, 95{\%} confidence interval [CI] 0.10-0.19; 6-8 cm, OR 0.06, 95{\%} CI 0.03-0.09; ≥9 cm, OR 0.03, 95{\%} CI 0.01-0.07). Stratified by BE length, nonadherence was associated with significantly decreased dysplasia detection (summary OR 0.53, 95{\%} CI 0.35-0.82). Conclusions: Adherence to BE biopsy guidelines in the community is low, and nonadherence is associated with significantly decreased dysplasia detection. Future studies should identify factors underlying nonadherence as well as mechanisms to increase adherence to guidelines to improve early detection of dysplasia.",
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AU - Kapel, Robert C.

AU - Lindberg, Guy M.

AU - Saboorian, Mohammad H.

AU - Genta, Robert M.

AU - Neugut, Alfred I.

AU - Lightdale, Charles J.

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N2 - Background & Aims: Current surveillance guidelines for Barrett's esophagus (BE) recommend extensive biopsies to minimize sampling error. Biopsy practice patterns for BE surveillance in the community have not been well-described. We used a national community-based pathology database to analyze adherence to guidelines and to determine whether adherence was associated with dysplasia detection. Methods: We identified 10,958 cases of established BE in the Caris Diagnostics pathology database from January 2002-April 2007. Demographic, pathologic, and endoscopic data were recorded. Dysplasia was categorized as low grade, high grade, or adenocarcinoma. Adherence was defined as ≥4 esophageal biopsies per 2 cm BE or a ratio ≥2.0. Generalized estimating equation multivariable analysis was performed to assess factors associated with adherence, adjusted for clustering by individual gastroenterologist. Results: A total of 2245 BE surveillance cases were identified with linked endoscopy reports that recorded BE length and could be assessed for adherence. Adherence to guidelines was seen in 51.2% of cases. In multivariable analysis, longer segment BE was associated with significantly reduced adherence (3-5 cm, odds ratio [OR] 0.14, 95% confidence interval [CI] 0.10-0.19; 6-8 cm, OR 0.06, 95% CI 0.03-0.09; ≥9 cm, OR 0.03, 95% CI 0.01-0.07). Stratified by BE length, nonadherence was associated with significantly decreased dysplasia detection (summary OR 0.53, 95% CI 0.35-0.82). Conclusions: Adherence to BE biopsy guidelines in the community is low, and nonadherence is associated with significantly decreased dysplasia detection. Future studies should identify factors underlying nonadherence as well as mechanisms to increase adherence to guidelines to improve early detection of dysplasia.

AB - Background & Aims: Current surveillance guidelines for Barrett's esophagus (BE) recommend extensive biopsies to minimize sampling error. Biopsy practice patterns for BE surveillance in the community have not been well-described. We used a national community-based pathology database to analyze adherence to guidelines and to determine whether adherence was associated with dysplasia detection. Methods: We identified 10,958 cases of established BE in the Caris Diagnostics pathology database from January 2002-April 2007. Demographic, pathologic, and endoscopic data were recorded. Dysplasia was categorized as low grade, high grade, or adenocarcinoma. Adherence was defined as ≥4 esophageal biopsies per 2 cm BE or a ratio ≥2.0. Generalized estimating equation multivariable analysis was performed to assess factors associated with adherence, adjusted for clustering by individual gastroenterologist. Results: A total of 2245 BE surveillance cases were identified with linked endoscopy reports that recorded BE length and could be assessed for adherence. Adherence to guidelines was seen in 51.2% of cases. In multivariable analysis, longer segment BE was associated with significantly reduced adherence (3-5 cm, odds ratio [OR] 0.14, 95% confidence interval [CI] 0.10-0.19; 6-8 cm, OR 0.06, 95% CI 0.03-0.09; ≥9 cm, OR 0.03, 95% CI 0.01-0.07). Stratified by BE length, nonadherence was associated with significantly decreased dysplasia detection (summary OR 0.53, 95% CI 0.35-0.82). Conclusions: Adherence to BE biopsy guidelines in the community is low, and nonadherence is associated with significantly decreased dysplasia detection. Future studies should identify factors underlying nonadherence as well as mechanisms to increase adherence to guidelines to improve early detection of dysplasia.

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