Adhesion dynamics of functional nanoparticles for targeted drug delivery

S. Shah, Y. Liu, W. Hu, J. Gao

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

Adhesion of micro and nanoparticles onto cardiovascular walls is a critical process in applications such as targeted drug delivery, biomedical imaging, and cancer treatment. This paper intends to develop an understanding of the dynamic interaction between particle and vessel wall through computational modeling. The ligand-receptor binding dynamics is coupled with Immersed Finite Element Method to study the adhesion process of particles with different shapes, bonding strengths, and physical configurations. Non-spherical particle is found to contact and adhere to the wall easier than spherical particle under the same configuration.

Original languageEnglish (US)
Title of host publication25th Southern Biomedical Engineering Conference 2009
Pages121-122
Number of pages2
DOIs
StatePublished - 2009
Event25th Southern Biomedical Engineering Conference 2009 - Miami, FL, United States
Duration: May 15 2009May 17 2009

Publication series

NameIFMBE Proceedings
Volume24
ISSN (Print)1680-0737

Other

Other25th Southern Biomedical Engineering Conference 2009
CountryUnited States
CityMiami, FL
Period5/15/095/17/09

Keywords

  • Adhesion dynamics
  • Drug delivery
  • Nanomedicine
  • Nanoparticle

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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