Appearance of local fibrotic structures around and beneath hair follicles during their involution is a known hallmark of androgenetic alopecia (AGA). We hypothesise that this fibrosis can be connected with recently uncovered adipocyte-myofibroblast transition (AMT) involving the dermal adipocytes. This reflects that AMT is at least partially androgen-dependent, and we propose that AMT may play a role in AGA.
- adipocyte-myofibroblast transition
- androgenetic alopecia
- perifollicular fibrosis
ASJC Scopus subject areas
- Molecular Biology