Adipocyte-myofibroblast transition as a possible pathophysiological step in androgenetic alopecia

Ilja L. Kruglikov; Philipp E. Scherer

doi:10.1111/exd.13379

Adipocyte-myofibroblast transition as a possible pathophysiological step in androgenetic alopecia

Ilja L. Kruglikov, Philipp E. Scherer

Research output: Contribution to journal › Letter › peer-review

13 Scopus citations

Abstract

Appearance of local fibrotic structures around and beneath hair follicles during their involution is a known hallmark of androgenetic alopecia (AGA). We hypothesise that this fibrosis can be connected with recently uncovered adipocyte-myofibroblast transition (AMT) involving the dermal adipocytes. This reflects that AMT is at least partially androgen-dependent, and we propose that AMT may play a role in AGA.

Original language	English (US)
Pages (from-to)	522-523
Number of pages	2
Journal	Experimental Dermatology
Volume	26
Issue number	6
DOIs	https://doi.org/10.1111/exd.13379
State	Published - Jun 2017

Keywords

adipocyte-myofibroblast transition
androgenetic alopecia
perifollicular fibrosis

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Dermatology

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10.1111/exd.13379

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title = "Adipocyte-myofibroblast transition as a possible pathophysiological step in androgenetic alopecia",

abstract = "Appearance of local fibrotic structures around and beneath hair follicles during their involution is a known hallmark of androgenetic alopecia (AGA). We hypothesise that this fibrosis can be connected with recently uncovered adipocyte-myofibroblast transition (AMT) involving the dermal adipocytes. This reflects that AMT is at least partially androgen-dependent, and we propose that AMT may play a role in AGA.",

keywords = "adipocyte-myofibroblast transition, androgenetic alopecia, perifollicular fibrosis",

author = "Kruglikov, {Ilja L.} and Scherer, {Philipp E.}",

note = "Funding Information: PES is supported by the National Institute of Health (R01-DK55758, R01-DK099110 and P01-DK088761) as well as a grant from the Cancer Prevention and Research Institute of Texas (CPRIT RP140412). Both I.L.K. and P.E.S. contributed to the ideas of this Hypothesis Letter and were involved in the writing. Figure created by Richard Howdy, certfied medical illustrator, at Visually Medical (http://www.visuallymedical.com)",

year = "2017",

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language = "English (US)",

volume = "26",

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journal = "Experimental Dermatology",

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AU - Kruglikov, Ilja L.

AU - Scherer, Philipp E.

N1 - Funding Information: PES is supported by the National Institute of Health (R01-DK55758, R01-DK099110 and P01-DK088761) as well as a grant from the Cancer Prevention and Research Institute of Texas (CPRIT RP140412). Both I.L.K. and P.E.S. contributed to the ideas of this Hypothesis Letter and were involved in the writing. Figure created by Richard Howdy, certfied medical illustrator, at Visually Medical (http://www.visuallymedical.com)

PY - 2017/6

Y1 - 2017/6

N2 - Appearance of local fibrotic structures around and beneath hair follicles during their involution is a known hallmark of androgenetic alopecia (AGA). We hypothesise that this fibrosis can be connected with recently uncovered adipocyte-myofibroblast transition (AMT) involving the dermal adipocytes. This reflects that AMT is at least partially androgen-dependent, and we propose that AMT may play a role in AGA.

AB - Appearance of local fibrotic structures around and beneath hair follicles during their involution is a known hallmark of androgenetic alopecia (AGA). We hypothesise that this fibrosis can be connected with recently uncovered adipocyte-myofibroblast transition (AMT) involving the dermal adipocytes. This reflects that AMT is at least partially androgen-dependent, and we propose that AMT may play a role in AGA.

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