Adipocyte-myofibroblast transition as a possible pathophysiological step in androgenetic alopecia

Ilja L. Kruglikov, Philipp E. Scherer

Research output: Contribution to journalLetter

11 Citations (Scopus)

Abstract

Appearance of local fibrotic structures around and beneath hair follicles during their involution is a known hallmark of androgenetic alopecia (AGA). We hypothesise that this fibrosis can be connected with recently uncovered adipocyte-myofibroblast transition (AMT) involving the dermal adipocytes. This reflects that AMT is at least partially androgen-dependent, and we propose that AMT may play a role in AGA.

Original languageEnglish (US)
Pages (from-to)522-523
Number of pages2
JournalExperimental Dermatology
Volume26
Issue number6
DOIs
StatePublished - Jun 1 2017

Fingerprint

Myofibroblasts
Alopecia
Adipocytes
Androgens
Hair Follicle
Fibrosis
Skin

Keywords

  • adipocyte-myofibroblast transition
  • androgenetic alopecia
  • perifollicular fibrosis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

Cite this

Adipocyte-myofibroblast transition as a possible pathophysiological step in androgenetic alopecia. / Kruglikov, Ilja L.; Scherer, Philipp E.

In: Experimental Dermatology, Vol. 26, No. 6, 01.06.2017, p. 522-523.

Research output: Contribution to journalLetter

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