Abstract
Appearance of local fibrotic structures around and beneath hair follicles during their involution is a known hallmark of androgenetic alopecia (AGA). We hypothesise that this fibrosis can be connected with recently uncovered adipocyte-myofibroblast transition (AMT) involving the dermal adipocytes. This reflects that AMT is at least partially androgen-dependent, and we propose that AMT may play a role in AGA.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 522-523 |
| Number of pages | 2 |
| Journal | Experimental Dermatology |
| Volume | 26 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1 2017 |
Fingerprint
Keywords
- adipocyte-myofibroblast transition
- androgenetic alopecia
- perifollicular fibrosis
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Dermatology
Cite this
Adipocyte-myofibroblast transition as a possible pathophysiological step in androgenetic alopecia. / Kruglikov, Ilja L.; Scherer, Philipp E.
In: Experimental Dermatology, Vol. 26, No. 6, 01.06.2017, p. 522-523.Research output: Contribution to journal › Letter
}
TY - JOUR
T1 - Adipocyte-myofibroblast transition as a possible pathophysiological step in androgenetic alopecia
AU - Kruglikov, Ilja L.
AU - Scherer, Philipp E.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Appearance of local fibrotic structures around and beneath hair follicles during their involution is a known hallmark of androgenetic alopecia (AGA). We hypothesise that this fibrosis can be connected with recently uncovered adipocyte-myofibroblast transition (AMT) involving the dermal adipocytes. This reflects that AMT is at least partially androgen-dependent, and we propose that AMT may play a role in AGA.
AB - Appearance of local fibrotic structures around and beneath hair follicles during their involution is a known hallmark of androgenetic alopecia (AGA). We hypothesise that this fibrosis can be connected with recently uncovered adipocyte-myofibroblast transition (AMT) involving the dermal adipocytes. This reflects that AMT is at least partially androgen-dependent, and we propose that AMT may play a role in AGA.
KW - adipocyte-myofibroblast transition
KW - androgenetic alopecia
KW - perifollicular fibrosis
UR - http://www.scopus.com/inward/record.url?scp=85020665131&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85020665131&partnerID=8YFLogxK
U2 - 10.1111/exd.13379
DO - 10.1111/exd.13379
M3 - Letter
C2 - 28482134
AN - SCOPUS:85020665131
VL - 26
SP - 522
EP - 523
JO - Experimental Dermatology
JF - Experimental Dermatology
SN - 0906-6705
IS - 6
ER -