TY - JOUR
T1 - Adipocytokine and ghrelin levels in relation to cardiovascular disease risk factors in women at midlife
T2 - Longitudinal associations
AU - Wildman, R. P.
AU - Mancuso, P.
AU - Wang, C.
AU - Kim, M.
AU - Scherer, P. E.
AU - Sowers, M. R.
N1 - Funding Information:
This work was supported by NIH Grant AR041384 (Sowers, PI). Dr Mancuso has grant support from NIH Grant HL077417.
PY - 2008/5
Y1 - 2008/5
N2 - Background: There are limited data concerning the relationships between changes in adipocytokines and cardiovascular disease (CVD) risk factors. Objective: To examine the longitudinal associations between leptin, adiponectin, resistin and ghrelin levels and CVD risk factor levels in women at midlife. Design: Prospective, observational study. Subjects and measurements: Leptin, adiponectin, resistin, ghrelin levels and CVD risk factors were measured in specimens collected from 40 women at 3 points in time corresponding to the pre-, peri- and postmenopause stages of their natural menopause transition. Results: In longitudinal analyses adjusted for CVD risk factors and leptin at the previous menopausal stage, aging, education, smoking and physical activity, greater increases in leptin over the menopause transition were associated with greater decreases in high-density lipoprotein cholesterol (HDL-c) and greater increases in diastolic blood pressure, glucose, insulin and insulin resistance (all P<0.05). Larger decreases in adiponectin over the menopause transition were associated with greater increases in systolic blood pressure, insulin and insulin resistance and with greater decreases in HDL-c. Greater increases in ghrelin levels over the menopausal transition were associated with greater low-density lipoprotein cholesterol increases (P=0.014). Resistin was not associated with CVD risk factor changes. Conclusion: There were significant adverse associations of adipocytokines and ghrelin with multiple CVD risk factor changes in women across midlife. Given that this time period is dynamic for CVD risk, these data underscore the need for additional prospective studies.
AB - Background: There are limited data concerning the relationships between changes in adipocytokines and cardiovascular disease (CVD) risk factors. Objective: To examine the longitudinal associations between leptin, adiponectin, resistin and ghrelin levels and CVD risk factor levels in women at midlife. Design: Prospective, observational study. Subjects and measurements: Leptin, adiponectin, resistin, ghrelin levels and CVD risk factors were measured in specimens collected from 40 women at 3 points in time corresponding to the pre-, peri- and postmenopause stages of their natural menopause transition. Results: In longitudinal analyses adjusted for CVD risk factors and leptin at the previous menopausal stage, aging, education, smoking and physical activity, greater increases in leptin over the menopause transition were associated with greater decreases in high-density lipoprotein cholesterol (HDL-c) and greater increases in diastolic blood pressure, glucose, insulin and insulin resistance (all P<0.05). Larger decreases in adiponectin over the menopause transition were associated with greater increases in systolic blood pressure, insulin and insulin resistance and with greater decreases in HDL-c. Greater increases in ghrelin levels over the menopausal transition were associated with greater low-density lipoprotein cholesterol increases (P=0.014). Resistin was not associated with CVD risk factor changes. Conclusion: There were significant adverse associations of adipocytokines and ghrelin with multiple CVD risk factor changes in women across midlife. Given that this time period is dynamic for CVD risk, these data underscore the need for additional prospective studies.
KW - Adipocytokines
KW - Adiponectin
KW - Cardiovascular risk factors
KW - Longitudinal
KW - Women
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U2 - 10.1038/sj.ijo.0803782
DO - 10.1038/sj.ijo.0803782
M3 - Article
C2 - 18180784
AN - SCOPUS:43449091901
SN - 0307-0565
VL - 32
SP - 740
EP - 748
JO - International Journal of Obesity
JF - International Journal of Obesity
IS - 5
ER -