Adipogenesis and metabolic health

Alexandra L. Ghaben, Philipp E Scherer

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Obesity is characterized by increased adipose tissue mass and has been associated with a strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public health issue of major proportion. The expansion of adipose depots can be driven either by the increase in adipocyte size (hypertrophy) or by the formation of new adipocytes from precursor differentiation in the process of adipogenesis (hyperplasia). Notably, adipocyte expansion through adipogenesis can offset the negative metabolic effects of obesity, and the mechanisms and regulators of this adaptive process are now emerging. Over the past several years, we have learned a considerable amount about how adipocyte fate is determined and how adipogenesis is regulated by signalling and systemic factors. We have also gained appreciation that the adipogenic niche can influence tissue adipogenic capability. Approaches aimed at increasing adipogenesis over adipocyte hypertrophy can now be explored as a means to treat metabolic diseases.

Original languageEnglish (US)
JournalNature Reviews Molecular Cell Biology
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Adipogenesis
Adipocytes
Health
Metabolic Diseases
Hypertrophy
Obesity
Hyperplasia
Adipose Tissue
Public Health
Neoplasms

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Adipogenesis and metabolic health. / Ghaben, Alexandra L.; Scherer, Philipp E.

In: Nature Reviews Molecular Cell Biology, 01.01.2019.

Research output: Contribution to journalArticle

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