Adiponectin and cardiovascular risk profile in patients with type 2 diabetes mellitus: Parameters associated with adiponectin complex distribution

Mark P. Hamilton, M. Odette Gore, Colby R. Ayers, Xinyu Wu, Darren K. McGuire, Philipp E. Scherer

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Aims: Plasma levels of the adipokine adiponectin are accepted as excellent correlates to metabolic health. Here, we aim to characterise associations between circulating plasma adiponectin complexes and baseline parameters in a population of patients with type 2 diabetes mellitus (DM) with increased risk of cardiovascular disease. Methods: We measured levels of high molecular weight (HMW), low molecular weight (LMW) and trimeric adiponectin. Results: The study population comprised 53 subjects, mean age 57 years, 36% non-white and 44% women, with an average body mass index (BMI) of 34 and duration of DM of 8.5 years. There was an established history of cardiovascular disease in 36% of the patients. BMI was inversely associated with the proportion of HMW adiponectin compared with LMW and trimeric adiponectin. Longer duration of DM correlated with an increased proportion of trimeric adiponectin. Conclusions: Patients with elevated BMI, longer history of diabetes and cardiovascular disease have lower levels of the higher order adiponectin complex. In addition, we have measured for the first time levels of trimeric adiponectin in a diabetic population using high resolution fast protein liquid chromatography (FPLC) analysis and identified trimeric adiponectin as a promising new biomarker for cardiovascular disease with a stronger correlative relationship to cardiovascular disease than HMW adiponectin.

Original languageEnglish (US)
Pages (from-to)190-194
Number of pages5
JournalDiabetes and Vascular Disease Research
Volume8
Issue number3
DOIs
StatePublished - Jul 1 2011

Keywords

  • Adipokine
  • Adiponectin isoforms
  • Biomarker
  • Cardiovascular disease marker
  • Metabolic syndrome

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

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