Adiponectin and leptin levels in HIV-infected subjects with insulin resistance and body fat redistribution

Dennis C. Mynarcik, Terry Combs, Margaret A. McNurlan, Philipp E. Scherer, Eugene Komaroff, Marie C. Gelato

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

In this study, we sought to determine the relationship between serum levels of leptin and adiponectin (Acrp30) in patients with HIV-associated lipodystrophy (HIV-LD). Three groups of subjects were studied; HIV-positive subjects with lipodystrophy (HIV-LD; n = 22), HIV-positive subjects without lipodystrophy (HIV; n = 17), and ethnicity- and body mass index-matched healthy control subjects (n = 20). Although total body fat from dual energy x-ray absorptiometry was similar in all three groups, the HIV-LD group had a significantly lower mean proportion of body fat in the limbs ± SEM (37.2% ± 2.2%) than either controls (49.8% ± 1.5%) or HIV subjects (45.7% ± 2.0%). The HIV-LD group also had the lowest mean insulin sensitivity ± SEM (5.11 ± 0.59 mg of glucose/[kg of lean body mass · min] vs. 10.2 ± 0.72 mg of glucose/[kg of lean body mass · min] in controls and 8.64 ± 0.69 mg of glucose/[kg of lean body mass · min] in the HIV group), Leptin levels were similar in all three groups and were significantly correlated to total body fat (r = 0.86; p < .001), but these levels did not correlate with either insulin sensitivity or limb fat. Mean Acrp30 levels ± SEM were lowest in the HIV-LD group (5,43 ± 0.44 μg/mL vs. 11.2 ± 1,4 μg/mL in the HIV group and 14.9 ± 1.8 μg/mL in control subjects), Further, Acrp30 levels were positively correlated with insulin sensitivity (r = 0.610; p < .001) and limb fat (r = 0.483; p < .001). However, the correlation between limb fat and insulin sensitivity disappeared when Acrp30 level and other potential mediators were removed from the association, suggesting that a deficiency in Acrp30 in subjects with HIV-LD may be part of the mechanism for the reduced insulin sensitivity.

Original languageEnglish (US)
Pages (from-to)514-520
Number of pages7
JournalJournal of Acquired Immune Deficiency Syndromes
Volume31
Issue number5
StatePublished - Dec 15 2002

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HIV-Associated Lipodystrophy Syndrome
Adiponectin
Leptin
Insulin Resistance
Adipose Tissue
HIV
Extremities
Lipodystrophy
Fats
Glucose
Healthy Volunteers
Body Mass Index
X-Rays

Keywords

  • Acrp30-Insulin resistance
  • HIV lipodystrophy
  • Leptin-Adiponectin

ASJC Scopus subject areas

  • Virology
  • Immunology

Cite this

Adiponectin and leptin levels in HIV-infected subjects with insulin resistance and body fat redistribution. / Mynarcik, Dennis C.; Combs, Terry; McNurlan, Margaret A.; Scherer, Philipp E.; Komaroff, Eugene; Gelato, Marie C.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 31, No. 5, 15.12.2002, p. 514-520.

Research output: Contribution to journalArticle

Mynarcik, Dennis C. ; Combs, Terry ; McNurlan, Margaret A. ; Scherer, Philipp E. ; Komaroff, Eugene ; Gelato, Marie C. / Adiponectin and leptin levels in HIV-infected subjects with insulin resistance and body fat redistribution. In: Journal of Acquired Immune Deficiency Syndromes. 2002 ; Vol. 31, No. 5. pp. 514-520.
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abstract = "In this study, we sought to determine the relationship between serum levels of leptin and adiponectin (Acrp30) in patients with HIV-associated lipodystrophy (HIV-LD). Three groups of subjects were studied; HIV-positive subjects with lipodystrophy (HIV-LD; n = 22), HIV-positive subjects without lipodystrophy (HIV; n = 17), and ethnicity- and body mass index-matched healthy control subjects (n = 20). Although total body fat from dual energy x-ray absorptiometry was similar in all three groups, the HIV-LD group had a significantly lower mean proportion of body fat in the limbs ± SEM (37.2{\%} ± 2.2{\%}) than either controls (49.8{\%} ± 1.5{\%}) or HIV subjects (45.7{\%} ± 2.0{\%}). The HIV-LD group also had the lowest mean insulin sensitivity ± SEM (5.11 ± 0.59 mg of glucose/[kg of lean body mass · min] vs. 10.2 ± 0.72 mg of glucose/[kg of lean body mass · min] in controls and 8.64 ± 0.69 mg of glucose/[kg of lean body mass · min] in the HIV group), Leptin levels were similar in all three groups and were significantly correlated to total body fat (r = 0.86; p < .001), but these levels did not correlate with either insulin sensitivity or limb fat. Mean Acrp30 levels ± SEM were lowest in the HIV-LD group (5,43 ± 0.44 μg/mL vs. 11.2 ± 1,4 μg/mL in the HIV group and 14.9 ± 1.8 μg/mL in control subjects), Further, Acrp30 levels were positively correlated with insulin sensitivity (r = 0.610; p < .001) and limb fat (r = 0.483; p < .001). However, the correlation between limb fat and insulin sensitivity disappeared when Acrp30 level and other potential mediators were removed from the association, suggesting that a deficiency in Acrp30 in subjects with HIV-LD may be part of the mechanism for the reduced insulin sensitivity.",
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AB - In this study, we sought to determine the relationship between serum levels of leptin and adiponectin (Acrp30) in patients with HIV-associated lipodystrophy (HIV-LD). Three groups of subjects were studied; HIV-positive subjects with lipodystrophy (HIV-LD; n = 22), HIV-positive subjects without lipodystrophy (HIV; n = 17), and ethnicity- and body mass index-matched healthy control subjects (n = 20). Although total body fat from dual energy x-ray absorptiometry was similar in all three groups, the HIV-LD group had a significantly lower mean proportion of body fat in the limbs ± SEM (37.2% ± 2.2%) than either controls (49.8% ± 1.5%) or HIV subjects (45.7% ± 2.0%). The HIV-LD group also had the lowest mean insulin sensitivity ± SEM (5.11 ± 0.59 mg of glucose/[kg of lean body mass · min] vs. 10.2 ± 0.72 mg of glucose/[kg of lean body mass · min] in controls and 8.64 ± 0.69 mg of glucose/[kg of lean body mass · min] in the HIV group), Leptin levels were similar in all three groups and were significantly correlated to total body fat (r = 0.86; p < .001), but these levels did not correlate with either insulin sensitivity or limb fat. Mean Acrp30 levels ± SEM were lowest in the HIV-LD group (5,43 ± 0.44 μg/mL vs. 11.2 ± 1,4 μg/mL in the HIV group and 14.9 ± 1.8 μg/mL in control subjects), Further, Acrp30 levels were positively correlated with insulin sensitivity (r = 0.610; p < .001) and limb fat (r = 0.483; p < .001). However, the correlation between limb fat and insulin sensitivity disappeared when Acrp30 level and other potential mediators were removed from the association, suggesting that a deficiency in Acrp30 in subjects with HIV-LD may be part of the mechanism for the reduced insulin sensitivity.

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