Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk

Research output: Contribution to journalArticle

167 Citations (Scopus)

Abstract

Metabolism research has made tremendous progress over the last several decades in establishing the adipocyte as a central rheostat in the regulation of systemic nutrient and energy homeostasis. Operating at multiple levels of control, the adipocyte communicates with organ systems to adjust gene expression, glucoregulatory hormone exocytosis, enzymatic reactions, and nutrient flux to equilibrate the metabolic demands of a positive or negative energy balance. The identification of these mechanisms has great potential to identify novel targets for the treatment of diabetes and related metabolic disorders. Herein, we review the central role of the adipocyte in the maintenance of metabolic homeostasis, highlighting three critical mediators: adiponectin, leptin, and fatty acids.

Original languageEnglish (US)
Pages (from-to)770-784
Number of pages15
JournalCell Metabolism
Volume23
Issue number5
DOIs
StatePublished - May 10 2016

Fingerprint

Adiponectin
Leptin
Adipocytes
Adipose Tissue
Homeostasis
Fatty Acids
Maintenance
Food
Exocytosis
Hormones
Gene Expression
Research

Keywords

  • adipokines
  • adiponectin
  • leptin
  • lipid signaling

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Physiology

Cite this

Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk. / Stern, Jennifer H.; Rutkowski, Joseph M.; Scherer, Philipp E.

In: Cell Metabolism, Vol. 23, No. 5, 10.05.2016, p. 770-784.

Research output: Contribution to journalArticle

@article{3633d468819e4d6d94eb39212ddffe79,
title = "Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk",
abstract = "Metabolism research has made tremendous progress over the last several decades in establishing the adipocyte as a central rheostat in the regulation of systemic nutrient and energy homeostasis. Operating at multiple levels of control, the adipocyte communicates with organ systems to adjust gene expression, glucoregulatory hormone exocytosis, enzymatic reactions, and nutrient flux to equilibrate the metabolic demands of a positive or negative energy balance. The identification of these mechanisms has great potential to identify novel targets for the treatment of diabetes and related metabolic disorders. Herein, we review the central role of the adipocyte in the maintenance of metabolic homeostasis, highlighting three critical mediators: adiponectin, leptin, and fatty acids.",
keywords = "adipokines, adiponectin, leptin, lipid signaling",
author = "Stern, {Jennifer H.} and Rutkowski, {Joseph M.} and Scherer, {Philipp E.}",
year = "2016",
month = "5",
day = "10",
doi = "10.1016/j.cmet.2016.04.011",
language = "English (US)",
volume = "23",
pages = "770--784",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "5",

}

TY - JOUR

T1 - Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk

AU - Stern, Jennifer H.

AU - Rutkowski, Joseph M.

AU - Scherer, Philipp E.

PY - 2016/5/10

Y1 - 2016/5/10

N2 - Metabolism research has made tremendous progress over the last several decades in establishing the adipocyte as a central rheostat in the regulation of systemic nutrient and energy homeostasis. Operating at multiple levels of control, the adipocyte communicates with organ systems to adjust gene expression, glucoregulatory hormone exocytosis, enzymatic reactions, and nutrient flux to equilibrate the metabolic demands of a positive or negative energy balance. The identification of these mechanisms has great potential to identify novel targets for the treatment of diabetes and related metabolic disorders. Herein, we review the central role of the adipocyte in the maintenance of metabolic homeostasis, highlighting three critical mediators: adiponectin, leptin, and fatty acids.

AB - Metabolism research has made tremendous progress over the last several decades in establishing the adipocyte as a central rheostat in the regulation of systemic nutrient and energy homeostasis. Operating at multiple levels of control, the adipocyte communicates with organ systems to adjust gene expression, glucoregulatory hormone exocytosis, enzymatic reactions, and nutrient flux to equilibrate the metabolic demands of a positive or negative energy balance. The identification of these mechanisms has great potential to identify novel targets for the treatment of diabetes and related metabolic disorders. Herein, we review the central role of the adipocyte in the maintenance of metabolic homeostasis, highlighting three critical mediators: adiponectin, leptin, and fatty acids.

KW - adipokines

KW - adiponectin

KW - leptin

KW - lipid signaling

UR - http://www.scopus.com/inward/record.url?scp=84966605886&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84966605886&partnerID=8YFLogxK

U2 - 10.1016/j.cmet.2016.04.011

DO - 10.1016/j.cmet.2016.04.011

M3 - Article

VL - 23

SP - 770

EP - 784

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 5

ER -