Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk

Jennifer H. Stern, Joseph M. Rutkowski, Philipp E. Scherer

Research output: Contribution to journalArticle

271 Scopus citations

Abstract

Metabolism research has made tremendous progress over the last several decades in establishing the adipocyte as a central rheostat in the regulation of systemic nutrient and energy homeostasis. Operating at multiple levels of control, the adipocyte communicates with organ systems to adjust gene expression, glucoregulatory hormone exocytosis, enzymatic reactions, and nutrient flux to equilibrate the metabolic demands of a positive or negative energy balance. The identification of these mechanisms has great potential to identify novel targets for the treatment of diabetes and related metabolic disorders. Herein, we review the central role of the adipocyte in the maintenance of metabolic homeostasis, highlighting three critical mediators: adiponectin, leptin, and fatty acids.

Original languageEnglish (US)
Pages (from-to)770-784
Number of pages15
JournalCell Metabolism
Volume23
Issue number5
DOIs
StatePublished - May 10 2016

Keywords

  • adipokines
  • adiponectin
  • leptin
  • lipid signaling

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Physiology

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