Adiponectin protects against incident hypertension independent of body fat distribution: Observations from the Dallas Heart Study

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Abstract

Background: Excess adipose tissue has been implicated in the pathogenesis of insulin resistance and atherosclerosis and is a key risk factor for blood pressure (BP) elevation. However, circulating levels of adiponectin, a protein produced by adipose tissue and widely implicated in the pathogenesis of insulin resistance and atherosclerosis, are inversely proportional to adiposity. The relationship between adiponectin and incident hypertension has not been determined in the general US population. Methods: Normotensive participants (n = 1233) enrolled in the Dallas Heart Study, a multiethnic, probability-based population sample of Dallas County adults were followed for median of 7 years. Retroperitoneal, intraperitoneal, visceral, and subcutaneous adipose tissue were measured at baseline by magnetic resonance imaging. Liver fat content was measured by 1H-magnetic resonance spectroscopy. Relative risk regression was used to determine the association of adiponectin with incident hypertension after adjustment for age, race, sex, BMI, smoking, diabetes, baseline systolic BP, total cholesterol, and regional fat depot. Results: Of the 1233 study participants (median age 40 years, 40% black, and 56% women), 391 (32%) had developed hypertension over a median follow-up of 7 years. Adiponectin levels were associated with reduced risk of incident hypertension (RR 0.81, 95% CI [0.68-0.96]) in the fully adjusted model, which included liver fat. Similar results were observed after adjustment for subcutaneous or visceral fat depots when tested individually or simultaneously in the model. Conclusion: Our study suggested a protective role of adiponectin against incident hypertension independent of body fat distribution.

Original languageEnglish (US)
JournalDiabetes/Metabolism Research and Reviews
DOIs
StateAccepted/In press - 2016

Fingerprint

Body Fat Distribution
Adiponectin
Intra-Abdominal Fat
Hypertension
Subcutaneous Fat
Fats
Blood Pressure
Insulin Resistance
Adipose Tissue
Atherosclerosis
Liver
Adiposity
Population
Magnetic Resonance Spectroscopy
Smoking
Cholesterol
Magnetic Resonance Imaging
Proteins

Keywords

  • Adiponectin
  • Fat
  • Hypertension
  • Leptin
  • Subcutaneous adipose tissue
  • Visceral adipose tissue

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

@article{3f4487c2f2ea44e3a214024b9d2e8c1e,
title = "Adiponectin protects against incident hypertension independent of body fat distribution: Observations from the Dallas Heart Study",
abstract = "Background: Excess adipose tissue has been implicated in the pathogenesis of insulin resistance and atherosclerosis and is a key risk factor for blood pressure (BP) elevation. However, circulating levels of adiponectin, a protein produced by adipose tissue and widely implicated in the pathogenesis of insulin resistance and atherosclerosis, are inversely proportional to adiposity. The relationship between adiponectin and incident hypertension has not been determined in the general US population. Methods: Normotensive participants (n = 1233) enrolled in the Dallas Heart Study, a multiethnic, probability-based population sample of Dallas County adults were followed for median of 7 years. Retroperitoneal, intraperitoneal, visceral, and subcutaneous adipose tissue were measured at baseline by magnetic resonance imaging. Liver fat content was measured by 1H-magnetic resonance spectroscopy. Relative risk regression was used to determine the association of adiponectin with incident hypertension after adjustment for age, race, sex, BMI, smoking, diabetes, baseline systolic BP, total cholesterol, and regional fat depot. Results: Of the 1233 study participants (median age 40 years, 40{\%} black, and 56{\%} women), 391 (32{\%}) had developed hypertension over a median follow-up of 7 years. Adiponectin levels were associated with reduced risk of incident hypertension (RR 0.81, 95{\%} CI [0.68-0.96]) in the fully adjusted model, which included liver fat. Similar results were observed after adjustment for subcutaneous or visceral fat depots when tested individually or simultaneously in the model. Conclusion: Our study suggested a protective role of adiponectin against incident hypertension independent of body fat distribution.",
keywords = "Adiponectin, Fat, Hypertension, Leptin, Subcutaneous adipose tissue, Visceral adipose tissue",
author = "Peri-Okonny, {Poghni A.} and Colby Ayers and Maalouf, {Naim M} and Das, {Sandeep R} and {de Lemos}, {James A} and Berry, {Jarett D} and Turer, {Aslan T} and Neeland, {Ian J} and Scherer, {Philipp E} and Wanpen Vongpatanasin",
year = "2016",
doi = "10.1002/dmrr.2840",
language = "English (US)",
journal = "Diabetes/Metabolism Research and Reviews",
issn = "1520-7552",
publisher = "John Wiley and Sons Ltd",

}

TY - JOUR

T1 - Adiponectin protects against incident hypertension independent of body fat distribution

T2 - Observations from the Dallas Heart Study

AU - Peri-Okonny, Poghni A.

AU - Ayers, Colby

AU - Maalouf, Naim M

AU - Das, Sandeep R

AU - de Lemos, James A

AU - Berry, Jarett D

AU - Turer, Aslan T

AU - Neeland, Ian J

AU - Scherer, Philipp E

AU - Vongpatanasin, Wanpen

PY - 2016

Y1 - 2016

N2 - Background: Excess adipose tissue has been implicated in the pathogenesis of insulin resistance and atherosclerosis and is a key risk factor for blood pressure (BP) elevation. However, circulating levels of adiponectin, a protein produced by adipose tissue and widely implicated in the pathogenesis of insulin resistance and atherosclerosis, are inversely proportional to adiposity. The relationship between adiponectin and incident hypertension has not been determined in the general US population. Methods: Normotensive participants (n = 1233) enrolled in the Dallas Heart Study, a multiethnic, probability-based population sample of Dallas County adults were followed for median of 7 years. Retroperitoneal, intraperitoneal, visceral, and subcutaneous adipose tissue were measured at baseline by magnetic resonance imaging. Liver fat content was measured by 1H-magnetic resonance spectroscopy. Relative risk regression was used to determine the association of adiponectin with incident hypertension after adjustment for age, race, sex, BMI, smoking, diabetes, baseline systolic BP, total cholesterol, and regional fat depot. Results: Of the 1233 study participants (median age 40 years, 40% black, and 56% women), 391 (32%) had developed hypertension over a median follow-up of 7 years. Adiponectin levels were associated with reduced risk of incident hypertension (RR 0.81, 95% CI [0.68-0.96]) in the fully adjusted model, which included liver fat. Similar results were observed after adjustment for subcutaneous or visceral fat depots when tested individually or simultaneously in the model. Conclusion: Our study suggested a protective role of adiponectin against incident hypertension independent of body fat distribution.

AB - Background: Excess adipose tissue has been implicated in the pathogenesis of insulin resistance and atherosclerosis and is a key risk factor for blood pressure (BP) elevation. However, circulating levels of adiponectin, a protein produced by adipose tissue and widely implicated in the pathogenesis of insulin resistance and atherosclerosis, are inversely proportional to adiposity. The relationship between adiponectin and incident hypertension has not been determined in the general US population. Methods: Normotensive participants (n = 1233) enrolled in the Dallas Heart Study, a multiethnic, probability-based population sample of Dallas County adults were followed for median of 7 years. Retroperitoneal, intraperitoneal, visceral, and subcutaneous adipose tissue were measured at baseline by magnetic resonance imaging. Liver fat content was measured by 1H-magnetic resonance spectroscopy. Relative risk regression was used to determine the association of adiponectin with incident hypertension after adjustment for age, race, sex, BMI, smoking, diabetes, baseline systolic BP, total cholesterol, and regional fat depot. Results: Of the 1233 study participants (median age 40 years, 40% black, and 56% women), 391 (32%) had developed hypertension over a median follow-up of 7 years. Adiponectin levels were associated with reduced risk of incident hypertension (RR 0.81, 95% CI [0.68-0.96]) in the fully adjusted model, which included liver fat. Similar results were observed after adjustment for subcutaneous or visceral fat depots when tested individually or simultaneously in the model. Conclusion: Our study suggested a protective role of adiponectin against incident hypertension independent of body fat distribution.

KW - Adiponectin

KW - Fat

KW - Hypertension

KW - Leptin

KW - Subcutaneous adipose tissue

KW - Visceral adipose tissue

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U2 - 10.1002/dmrr.2840

DO - 10.1002/dmrr.2840

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JO - Diabetes/Metabolism Research and Reviews

JF - Diabetes/Metabolism Research and Reviews

SN - 1520-7552

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