Adiponectin protects the rats liver against chronic intermittent hypoxia induced injury through AMP-activated protein kinase pathway

Wenxiao Ding, Qiang Zhang, Yanbin Dong, Ning Ding, Hanpeng Huang, Xianji Zhu, Sean Hutchinson, Xingya Gao, Xilong Zhang

Research output: Contribution to journalArticle

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Abstract

This study was performed to assess the effect of chronic intermittent hypoxia (CIH) on the liver, the associated mechanisms and the potential therapeutic roles of adiponectin (Ad). Sixty rats were randomly assigned to four groups: the normal control (NC), NC and Ad supplement (NC + Ad), CIH, and CIH and Ad supplement (CIH + Ad) groups. The rats in the CIH and CIH + Ad groups were exposed to a hypoxic environment for 4 months. Rats in the NC + Ad and CIH + Ad groups were also treated with an intravenous injection of Ad (10 ug), twice a week. The plasma levels of hepatic enzymes, serum triglyceride, liver triglyceride, fasting blood glucose and hepatic cell apoptosis in hepatic tissue, were higher in the CIH group than in the NC and NC + Ad groups. However, the Ad supplementation in the CIH + Ad group rescued the hepatic tissue insult by activating the AMP-activated protein kinase (AMPK) pathway. In conclusion, Ad could protect against CIH-induced hepatic injury partly through the AMPK pathway.

Original languageEnglish (US)
Article number34151
JournalScientific reports
Volume6
DOIs
StatePublished - Sep 28 2016
Externally publishedYes

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AMP-Activated Protein Kinases
Adiponectin
Liver
Wounds and Injuries
rat Adipoq protein
Hypoxia
Triglycerides
Control Groups
Intravenous Injections
Blood Glucose
Hepatocytes
Fasting
Blood Cells

ASJC Scopus subject areas

  • General

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Adiponectin protects the rats liver against chronic intermittent hypoxia induced injury through AMP-activated protein kinase pathway. / Ding, Wenxiao; Zhang, Qiang; Dong, Yanbin; Ding, Ning; Huang, Hanpeng; Zhu, Xianji; Hutchinson, Sean; Gao, Xingya; Zhang, Xilong.

In: Scientific reports, Vol. 6, 34151, 28.09.2016.

Research output: Contribution to journalArticle

Ding, Wenxiao ; Zhang, Qiang ; Dong, Yanbin ; Ding, Ning ; Huang, Hanpeng ; Zhu, Xianji ; Hutchinson, Sean ; Gao, Xingya ; Zhang, Xilong. / Adiponectin protects the rats liver against chronic intermittent hypoxia induced injury through AMP-activated protein kinase pathway. In: Scientific reports. 2016 ; Vol. 6.
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AU - Zhu, Xianji

AU - Hutchinson, Sean

AU - Gao, Xingya

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