Adiponectin, the past two decades

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

Adiponectin is an adipocyte-specific factor, first described in 1995. Over the past two decades, numerous studies have elucidated the physiological functions of adiponectin in obesity, diabetes, inflammation, atherosclerosis, and cardiovascular disease. Adiponectin, elicited through cognate receptors, suppresses glucose production in the liver and enhances fatty acid oxidation in skeletal muscle, which together contribute to a beneficial metabolic action in whole body energy homeostasis. Beyond its role in metabolism, adiponectin also protects cells from apoptosis and reduces inflammation in various cell types via receptor-dependent mechanisms. Adiponectin, as a fat-derived hormone, therefore fulfills a critical role as an important messenger to communicate between adipose tissue and other organs. A better understanding of adiponectin actions, including the pros and cons, will advance our insights into basic mechanisms of metabolism and inflammation, and potentially pave the way toward novel means of pharmacological intervention to address pathophysiological changes associated with diabetes, atherosclerosis, and cardiometabolic disease.

Original languageEnglish (US)
Pages (from-to)93-100
Number of pages8
JournalJournal of Molecular Cell Biology
Volume8
Issue number2
DOIs
StatePublished - Apr 1 2016

Fingerprint

Adiponectin
Inflammation
Atherosclerosis
Adipocytes
Adipose Tissue
Skeletal Muscle
Homeostasis
Cardiovascular Diseases
Fatty Acids
Obesity
Fats
Hormones
Pharmacology
Apoptosis
Liver

Keywords

  • adiponectin
  • diabetes
  • metabolic syndrome
  • obesity

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology
  • Genetics

Cite this

Adiponectin, the past two decades. / Wang, Zhao V.; Scherer, Philipp E.

In: Journal of Molecular Cell Biology, Vol. 8, No. 2, 01.04.2016, p. 93-100.

Research output: Contribution to journalArticle

@article{fd722e9091fb46868bbfc7b80cc18502,
title = "Adiponectin, the past two decades",
abstract = "Adiponectin is an adipocyte-specific factor, first described in 1995. Over the past two decades, numerous studies have elucidated the physiological functions of adiponectin in obesity, diabetes, inflammation, atherosclerosis, and cardiovascular disease. Adiponectin, elicited through cognate receptors, suppresses glucose production in the liver and enhances fatty acid oxidation in skeletal muscle, which together contribute to a beneficial metabolic action in whole body energy homeostasis. Beyond its role in metabolism, adiponectin also protects cells from apoptosis and reduces inflammation in various cell types via receptor-dependent mechanisms. Adiponectin, as a fat-derived hormone, therefore fulfills a critical role as an important messenger to communicate between adipose tissue and other organs. A better understanding of adiponectin actions, including the pros and cons, will advance our insights into basic mechanisms of metabolism and inflammation, and potentially pave the way toward novel means of pharmacological intervention to address pathophysiological changes associated with diabetes, atherosclerosis, and cardiometabolic disease.",
keywords = "adiponectin, diabetes, metabolic syndrome, obesity",
author = "Wang, {Zhao V.} and Scherer, {Philipp E.}",
year = "2016",
month = "4",
day = "1",
doi = "10.1093/jmcb/mjw011",
language = "English (US)",
volume = "8",
pages = "93--100",
journal = "Journal of Molecular Cell Biology",
issn = "1674-2788",
publisher = "Oxford University Press",
number = "2",

}

TY - JOUR

T1 - Adiponectin, the past two decades

AU - Wang, Zhao V.

AU - Scherer, Philipp E.

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Adiponectin is an adipocyte-specific factor, first described in 1995. Over the past two decades, numerous studies have elucidated the physiological functions of adiponectin in obesity, diabetes, inflammation, atherosclerosis, and cardiovascular disease. Adiponectin, elicited through cognate receptors, suppresses glucose production in the liver and enhances fatty acid oxidation in skeletal muscle, which together contribute to a beneficial metabolic action in whole body energy homeostasis. Beyond its role in metabolism, adiponectin also protects cells from apoptosis and reduces inflammation in various cell types via receptor-dependent mechanisms. Adiponectin, as a fat-derived hormone, therefore fulfills a critical role as an important messenger to communicate between adipose tissue and other organs. A better understanding of adiponectin actions, including the pros and cons, will advance our insights into basic mechanisms of metabolism and inflammation, and potentially pave the way toward novel means of pharmacological intervention to address pathophysiological changes associated with diabetes, atherosclerosis, and cardiometabolic disease.

AB - Adiponectin is an adipocyte-specific factor, first described in 1995. Over the past two decades, numerous studies have elucidated the physiological functions of adiponectin in obesity, diabetes, inflammation, atherosclerosis, and cardiovascular disease. Adiponectin, elicited through cognate receptors, suppresses glucose production in the liver and enhances fatty acid oxidation in skeletal muscle, which together contribute to a beneficial metabolic action in whole body energy homeostasis. Beyond its role in metabolism, adiponectin also protects cells from apoptosis and reduces inflammation in various cell types via receptor-dependent mechanisms. Adiponectin, as a fat-derived hormone, therefore fulfills a critical role as an important messenger to communicate between adipose tissue and other organs. A better understanding of adiponectin actions, including the pros and cons, will advance our insights into basic mechanisms of metabolism and inflammation, and potentially pave the way toward novel means of pharmacological intervention to address pathophysiological changes associated with diabetes, atherosclerosis, and cardiometabolic disease.

KW - adiponectin

KW - diabetes

KW - metabolic syndrome

KW - obesity

UR - http://www.scopus.com/inward/record.url?scp=84965060865&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84965060865&partnerID=8YFLogxK

U2 - 10.1093/jmcb/mjw011

DO - 10.1093/jmcb/mjw011

M3 - Article

C2 - 26993047

AN - SCOPUS:84965060865

VL - 8

SP - 93

EP - 100

JO - Journal of Molecular Cell Biology

JF - Journal of Molecular Cell Biology

SN - 1674-2788

IS - 2

ER -