Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance

Chong Yew Tan, Samuel Virtue, Steven Murfitt, Lee D. Robert, Yi Hui Phua, Martin Dale, Julian L. Griffin, Francisco Tinahones, Philipp E. Scherer, Antonio Vidal-Puig

Research output: Contribution to journalArticle

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Abstract

The non-essential fatty acids, C18:1n9, C16:0, C16:1n7, C18:0 and C18:1n7 account for over 75% of fatty acids in white adipose (WAT) triacylglycerol (TAG). The relative composition of these fatty acids (FA) is influenced by the desaturases, SCD1-4 and the elongase, ELOVL6. In knock-out models, loss of SCD1 or ELOVL6 results in reduced Δ9 desaturated and reduced 18-carbon non-essential FA respectively. Both Elovl6 KO and SCD1 KO mice exhibit improved insulin sensitivity. Here we describe the relationship between WAT TAG composition in obese mouse models and obese humans stratified for insulin resistance. In mouse models with increasing obesity and insulin resistance, there was an increase in scWAT Δ9 desaturated FAs (SCD ratio) and FAs with 18-carbons (Elovl6 ratio) in mice. Data from mouse models discordant for obesity and insulin resistance (AKT2 KO, Adiponectin aP2-transgenic), suggested that scWAT TAG Elovl6 ratio was associated with insulin sensitivity, whereas SCD1 ratio was associated with fat mass. In humans, a greater SCD1 and Elovl6 ratio was found in metabolically more harmful visceral adipose tissue when compared to subcutaneous adipose tissue.

Original languageEnglish (US)
Article number18366
JournalScientific Reports
Volume5
DOIs
StatePublished - Dec 17 2015

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Insulin Resistance
Adipose Tissue
Fatty Acids
Obesity
Triglycerides
Carbon
Obese Mice
Intra-Abdominal Fat
Subcutaneous Fat
Adiponectin
Fats

ASJC Scopus subject areas

  • General

Cite this

Yew Tan, C., Virtue, S., Murfitt, S., Robert, L. D., Phua, Y. H., Dale, M., ... Vidal-Puig, A. (2015). Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance. Scientific Reports, 5, [18366]. https://doi.org/10.1038/srep18366

Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance. / Yew Tan, Chong; Virtue, Samuel; Murfitt, Steven; Robert, Lee D.; Phua, Yi Hui; Dale, Martin; Griffin, Julian L.; Tinahones, Francisco; Scherer, Philipp E.; Vidal-Puig, Antonio.

In: Scientific Reports, Vol. 5, 18366, 17.12.2015.

Research output: Contribution to journalArticle

Yew Tan, C, Virtue, S, Murfitt, S, Robert, LD, Phua, YH, Dale, M, Griffin, JL, Tinahones, F, Scherer, PE & Vidal-Puig, A 2015, 'Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance', Scientific Reports, vol. 5, 18366. https://doi.org/10.1038/srep18366
Yew Tan, Chong ; Virtue, Samuel ; Murfitt, Steven ; Robert, Lee D. ; Phua, Yi Hui ; Dale, Martin ; Griffin, Julian L. ; Tinahones, Francisco ; Scherer, Philipp E. ; Vidal-Puig, Antonio. / Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance. In: Scientific Reports. 2015 ; Vol. 5.
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