Adipose tissue remodeling and obesity

Research output: Contribution to journalArticle

780 Citations (Scopus)

Abstract

To fulfill its role as the major energy-storing tissue, adipose has several unique properties that cannot be seen in any other organ, including an almost unlimited capacity to expand in a non-transformed state. As such, the tissue requires potent mechanisms to remodel, acutely and chronically. Adipocytes can rapidly reach the diffusional limit of oxygen during growth; hypoxia is therefore an early determinant that limits healthy expansion. Proper expansion requires a highly coordinated response among many different cell types, including endothelial precursor cells, immune cells, and preadipocytes. There are therefore remarkable similarities between adipose expansion and growth of solid tumors, a phenomenon that presents both an opportunity and a challenge, since pharmacological interventions supporting healthy adipose tissue adaptation can also facilitate tumor growth.

Original languageEnglish (US)
Pages (from-to)2094-2101
Number of pages8
JournalJournal of Clinical Investigation
Volume121
Issue number6
DOIs
StatePublished - Jun 1 2011

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Adipose Tissue
Obesity
Growth
Adipocytes
Neoplasms
Endothelial Cells
Pharmacology
Oxygen
Hypoxia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Adipose tissue remodeling and obesity. / Sun, Kai; Kusminski, Christine M.; Scherer, Philipp E.

In: Journal of Clinical Investigation, Vol. 121, No. 6, 01.06.2011, p. 2094-2101.

Research output: Contribution to journalArticle

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