Adipose tissue remodeling and obesity

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Abstract

To fulfill its role as the major energy-storing tissue, adipose has several unique properties that cannot be seen in any other organ, including an almost unlimited capacity to expand in a non-transformed state. As such, the tissue requires potent mechanisms to remodel, acutely and chronically. Adipocytes can rapidly reach the diffusional limit of oxygen during growth; hypoxia is therefore an early determinant that limits healthy expansion. Proper expansion requires a highly coordinated response among many different cell types, including endothelial precursor cells, immune cells, and preadipocytes. There are therefore remarkable similarities between adipose expansion and growth of solid tumors, a phenomenon that presents both an opportunity and a challenge, since pharmacological interventions supporting healthy adipose tissue adaptation can also facilitate tumor growth.

Original languageEnglish (US)
Pages (from-to)2094-2101
Number of pages8
JournalJournal of Clinical Investigation
Volume121
Issue number6
DOIs
Publication statusPublished - Jun 1 2011

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ASJC Scopus subject areas

  • Medicine(all)

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