Adipose Tissue Resistin Expression is Severely Suppressed in Obesity and Stimulated by Peroxisome Proliferator-activated Receptor γ Agonists

James M. Way, Cem Z. Görgün, Qiang Tong, K. Teoman Uysal, Kathleen K. Brown, W. Wallace Harrington, William R. Oliver, Timothy M. Willson, Steven A. Kliewer, Gökhan S. Hotamisligil

Research output: Contribution to journalArticle

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Abstract

Elevated levels of the hormone resistin, which is secreted by fat cells, are proposed to cause insulin resistance and to serve as a link between obesity and type 2 diabetes. In this report we show that resistin expression is significantly decreased in the white adipose tissue of several different models of obesity including the ob/ob, db/db, tub/tub, and KKAy mice compared with their lean counterparts. Furthermore, in response to several different classes of antidiabetic peroxisome proliferator-activated receptor γ agonists, adipose tissue resistin expression is increased in both ob/ob mice and Zucker diabetic fatty rats. These data demonstrate that experimental obesity in rodents is associated with severely defective resistin expression, and decreases in resistin expression are not required for the antidiabetic actions of peroxisome proliferator-activated receptor γ agonists.

Original languageEnglish (US)
Pages (from-to)25651-25653
Number of pages3
JournalJournal of Biological Chemistry
Volume276
Issue number28
DOIs
StatePublished - Jul 13 2001

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Resistin
Peroxisome Proliferator-Activated Receptors
Adipose Tissue
Obesity
Tissue
Hypoglycemic Agents
White Adipose Tissue
Medical problems
Adipocytes
Type 2 Diabetes Mellitus
Insulin Resistance
Rats
Rodentia
Fats
Hormones
Insulin

ASJC Scopus subject areas

  • Biochemistry

Cite this

Way, J. M., Görgün, C. Z., Tong, Q., Uysal, K. T., Brown, K. K., Harrington, W. W., ... Hotamisligil, G. S. (2001). Adipose Tissue Resistin Expression is Severely Suppressed in Obesity and Stimulated by Peroxisome Proliferator-activated Receptor γ Agonists. Journal of Biological Chemistry, 276(28), 25651-25653. https://doi.org/10.1074/jbc.C100189200

Adipose Tissue Resistin Expression is Severely Suppressed in Obesity and Stimulated by Peroxisome Proliferator-activated Receptor γ Agonists. / Way, James M.; Görgün, Cem Z.; Tong, Qiang; Uysal, K. Teoman; Brown, Kathleen K.; Harrington, W. Wallace; Oliver, William R.; Willson, Timothy M.; Kliewer, Steven A.; Hotamisligil, Gökhan S.

In: Journal of Biological Chemistry, Vol. 276, No. 28, 13.07.2001, p. 25651-25653.

Research output: Contribution to journalArticle

Way, JM, Görgün, CZ, Tong, Q, Uysal, KT, Brown, KK, Harrington, WW, Oliver, WR, Willson, TM, Kliewer, SA & Hotamisligil, GS 2001, 'Adipose Tissue Resistin Expression is Severely Suppressed in Obesity and Stimulated by Peroxisome Proliferator-activated Receptor γ Agonists', Journal of Biological Chemistry, vol. 276, no. 28, pp. 25651-25653. https://doi.org/10.1074/jbc.C100189200
Way, James M. ; Görgün, Cem Z. ; Tong, Qiang ; Uysal, K. Teoman ; Brown, Kathleen K. ; Harrington, W. Wallace ; Oliver, William R. ; Willson, Timothy M. ; Kliewer, Steven A. ; Hotamisligil, Gökhan S. / Adipose Tissue Resistin Expression is Severely Suppressed in Obesity and Stimulated by Peroxisome Proliferator-activated Receptor γ Agonists. In: Journal of Biological Chemistry. 2001 ; Vol. 276, No. 28. pp. 25651-25653.
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