TY - JOUR
T1 - Adipose Tissue Resistin Expression is Severely Suppressed in Obesity and Stimulated by Peroxisome Proliferator-activated Receptor γ Agonists
AU - Way, James M.
AU - Görgün, Cem Z.
AU - Tong, Qiang
AU - Uysal, K. Teoman
AU - Brown, Kathleen K.
AU - Harrington, W. Wallace
AU - Oliver, William R.
AU - Willson, Timothy M.
AU - Kliewer, Steven A.
AU - Hotamisligil, Gökhan S.
PY - 2001/7/13
Y1 - 2001/7/13
N2 - Elevated levels of the hormone resistin, which is secreted by fat cells, are proposed to cause insulin resistance and to serve as a link between obesity and type 2 diabetes. In this report we show that resistin expression is significantly decreased in the white adipose tissue of several different models of obesity including the ob/ob, db/db, tub/tub, and KKAy mice compared with their lean counterparts. Furthermore, in response to several different classes of antidiabetic peroxisome proliferator-activated receptor γ agonists, adipose tissue resistin expression is increased in both ob/ob mice and Zucker diabetic fatty rats. These data demonstrate that experimental obesity in rodents is associated with severely defective resistin expression, and decreases in resistin expression are not required for the antidiabetic actions of peroxisome proliferator-activated receptor γ agonists.
AB - Elevated levels of the hormone resistin, which is secreted by fat cells, are proposed to cause insulin resistance and to serve as a link between obesity and type 2 diabetes. In this report we show that resistin expression is significantly decreased in the white adipose tissue of several different models of obesity including the ob/ob, db/db, tub/tub, and KKAy mice compared with their lean counterparts. Furthermore, in response to several different classes of antidiabetic peroxisome proliferator-activated receptor γ agonists, adipose tissue resistin expression is increased in both ob/ob mice and Zucker diabetic fatty rats. These data demonstrate that experimental obesity in rodents is associated with severely defective resistin expression, and decreases in resistin expression are not required for the antidiabetic actions of peroxisome proliferator-activated receptor γ agonists.
UR - http://www.scopus.com/inward/record.url?scp=0242641149&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0242641149&partnerID=8YFLogxK
U2 - 10.1074/jbc.C100189200
DO - 10.1074/jbc.C100189200
M3 - Article
C2 - 11373275
AN - SCOPUS:0242641149
SN - 0021-9258
VL - 276
SP - 25651
EP - 25653
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 28
ER -