Adiposity, fat distribution, and cardiovascular risk

A. N. Peiris, M. S. Sothmann, R. G. Hoffmann, M. I. Hennes, C. R. Wilson, A. B. Gustafson, A. H. Kissebah

Research output: Contribution to journalArticle

387 Citations (Scopus)

Abstract

Study Objective: To determine the relative importance of adiposity and fat distribution to cardiovascular risk profile. Design: A cross-sectional study. Setting: Clinical research center funded by the National Institutes of Health. Patients: Convenience sample of 33 healthy premenopausal women with a wide range of body weight who did not have diabetes mellitus, hirsutism and virilism, gynecologic disorder, cardiac disease, or hypertension. Women participating in exercise or dietary programs or taking medication were excluded. All subjects completed the study. Interventions: Total body fat mass was determined by hydrostatic weighing, and fat distribution was assessed by subscapular skinfold thickness, subscapular-to-triceps skinfold ratio, the waist-to-hip ratio, and computed tomography. Cardiovascular risk was assessed by the serum insulin response during oral glucose stimulation; levels of triglycerides and total cholesterol; high-density lipoprotein cholesterol to total cholesterol concentrations; and systolic and diastolic blood pressures. Measurements and Main Results: The anthropometric parameters chosen were significantly associated with the cardiovascular risk profile (P < 0.001). Visceral fat distribution assessed by computed tomography accounted for a significantly greater degree of variance in the cardiovascular risk factors than the total body fat mass (P < 0.05). The cumulative insulin response was the primary metabolic variable relating the anthropometric indices to cardiovascular risk. Conclusions: Intra-abdominal fat deposition constitutes a greater cardiovascular risk than obestiy alone. Hyperinsulinemia may constitute an important component of the increased cardiovascular risk of abdominal obesity.

Original languageEnglish (US)
Pages (from-to)867-872
Number of pages6
JournalAnnals of Internal Medicine
Volume110
Issue number11
StatePublished - 1989

Fingerprint

Adiposity
Fats
Intra-Abdominal Fat
Adipose Tissue
Cholesterol
Tomography
Insulin
Blood Pressure
Virilism
Hirsutism
Skinfold Thickness
Waist-Hip Ratio
Abdominal Obesity
National Institutes of Health (U.S.)
Hyperinsulinism
HDL Cholesterol
Heart Diseases
Diabetes Mellitus
Triglycerides
Cross-Sectional Studies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Peiris, A. N., Sothmann, M. S., Hoffmann, R. G., Hennes, M. I., Wilson, C. R., Gustafson, A. B., & Kissebah, A. H. (1989). Adiposity, fat distribution, and cardiovascular risk. Annals of Internal Medicine, 110(11), 867-872.

Adiposity, fat distribution, and cardiovascular risk. / Peiris, A. N.; Sothmann, M. S.; Hoffmann, R. G.; Hennes, M. I.; Wilson, C. R.; Gustafson, A. B.; Kissebah, A. H.

In: Annals of Internal Medicine, Vol. 110, No. 11, 1989, p. 867-872.

Research output: Contribution to journalArticle

Peiris, AN, Sothmann, MS, Hoffmann, RG, Hennes, MI, Wilson, CR, Gustafson, AB & Kissebah, AH 1989, 'Adiposity, fat distribution, and cardiovascular risk', Annals of Internal Medicine, vol. 110, no. 11, pp. 867-872.
Peiris AN, Sothmann MS, Hoffmann RG, Hennes MI, Wilson CR, Gustafson AB et al. Adiposity, fat distribution, and cardiovascular risk. Annals of Internal Medicine. 1989;110(11):867-872.
Peiris, A. N. ; Sothmann, M. S. ; Hoffmann, R. G. ; Hennes, M. I. ; Wilson, C. R. ; Gustafson, A. B. ; Kissebah, A. H. / Adiposity, fat distribution, and cardiovascular risk. In: Annals of Internal Medicine. 1989 ; Vol. 110, No. 11. pp. 867-872.
@article{3d7cd1b5b3e9495c82f615e9285aab3b,
title = "Adiposity, fat distribution, and cardiovascular risk",
abstract = "Study Objective: To determine the relative importance of adiposity and fat distribution to cardiovascular risk profile. Design: A cross-sectional study. Setting: Clinical research center funded by the National Institutes of Health. Patients: Convenience sample of 33 healthy premenopausal women with a wide range of body weight who did not have diabetes mellitus, hirsutism and virilism, gynecologic disorder, cardiac disease, or hypertension. Women participating in exercise or dietary programs or taking medication were excluded. All subjects completed the study. Interventions: Total body fat mass was determined by hydrostatic weighing, and fat distribution was assessed by subscapular skinfold thickness, subscapular-to-triceps skinfold ratio, the waist-to-hip ratio, and computed tomography. Cardiovascular risk was assessed by the serum insulin response during oral glucose stimulation; levels of triglycerides and total cholesterol; high-density lipoprotein cholesterol to total cholesterol concentrations; and systolic and diastolic blood pressures. Measurements and Main Results: The anthropometric parameters chosen were significantly associated with the cardiovascular risk profile (P < 0.001). Visceral fat distribution assessed by computed tomography accounted for a significantly greater degree of variance in the cardiovascular risk factors than the total body fat mass (P < 0.05). The cumulative insulin response was the primary metabolic variable relating the anthropometric indices to cardiovascular risk. Conclusions: Intra-abdominal fat deposition constitutes a greater cardiovascular risk than obestiy alone. Hyperinsulinemia may constitute an important component of the increased cardiovascular risk of abdominal obesity.",
author = "Peiris, {A. N.} and Sothmann, {M. S.} and Hoffmann, {R. G.} and Hennes, {M. I.} and Wilson, {C. R.} and Gustafson, {A. B.} and Kissebah, {A. H.}",
year = "1989",
language = "English (US)",
volume = "110",
pages = "867--872",
journal = "Annals of Internal Medicine",
issn = "0003-4819",
publisher = "American College of Physicians",
number = "11",

}

TY - JOUR

T1 - Adiposity, fat distribution, and cardiovascular risk

AU - Peiris, A. N.

AU - Sothmann, M. S.

AU - Hoffmann, R. G.

AU - Hennes, M. I.

AU - Wilson, C. R.

AU - Gustafson, A. B.

AU - Kissebah, A. H.

PY - 1989

Y1 - 1989

N2 - Study Objective: To determine the relative importance of adiposity and fat distribution to cardiovascular risk profile. Design: A cross-sectional study. Setting: Clinical research center funded by the National Institutes of Health. Patients: Convenience sample of 33 healthy premenopausal women with a wide range of body weight who did not have diabetes mellitus, hirsutism and virilism, gynecologic disorder, cardiac disease, or hypertension. Women participating in exercise or dietary programs or taking medication were excluded. All subjects completed the study. Interventions: Total body fat mass was determined by hydrostatic weighing, and fat distribution was assessed by subscapular skinfold thickness, subscapular-to-triceps skinfold ratio, the waist-to-hip ratio, and computed tomography. Cardiovascular risk was assessed by the serum insulin response during oral glucose stimulation; levels of triglycerides and total cholesterol; high-density lipoprotein cholesterol to total cholesterol concentrations; and systolic and diastolic blood pressures. Measurements and Main Results: The anthropometric parameters chosen were significantly associated with the cardiovascular risk profile (P < 0.001). Visceral fat distribution assessed by computed tomography accounted for a significantly greater degree of variance in the cardiovascular risk factors than the total body fat mass (P < 0.05). The cumulative insulin response was the primary metabolic variable relating the anthropometric indices to cardiovascular risk. Conclusions: Intra-abdominal fat deposition constitutes a greater cardiovascular risk than obestiy alone. Hyperinsulinemia may constitute an important component of the increased cardiovascular risk of abdominal obesity.

AB - Study Objective: To determine the relative importance of adiposity and fat distribution to cardiovascular risk profile. Design: A cross-sectional study. Setting: Clinical research center funded by the National Institutes of Health. Patients: Convenience sample of 33 healthy premenopausal women with a wide range of body weight who did not have diabetes mellitus, hirsutism and virilism, gynecologic disorder, cardiac disease, or hypertension. Women participating in exercise or dietary programs or taking medication were excluded. All subjects completed the study. Interventions: Total body fat mass was determined by hydrostatic weighing, and fat distribution was assessed by subscapular skinfold thickness, subscapular-to-triceps skinfold ratio, the waist-to-hip ratio, and computed tomography. Cardiovascular risk was assessed by the serum insulin response during oral glucose stimulation; levels of triglycerides and total cholesterol; high-density lipoprotein cholesterol to total cholesterol concentrations; and systolic and diastolic blood pressures. Measurements and Main Results: The anthropometric parameters chosen were significantly associated with the cardiovascular risk profile (P < 0.001). Visceral fat distribution assessed by computed tomography accounted for a significantly greater degree of variance in the cardiovascular risk factors than the total body fat mass (P < 0.05). The cumulative insulin response was the primary metabolic variable relating the anthropometric indices to cardiovascular risk. Conclusions: Intra-abdominal fat deposition constitutes a greater cardiovascular risk than obestiy alone. Hyperinsulinemia may constitute an important component of the increased cardiovascular risk of abdominal obesity.

UR - http://www.scopus.com/inward/record.url?scp=0024343365&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024343365&partnerID=8YFLogxK

M3 - Article

VL - 110

SP - 867

EP - 872

JO - Annals of Internal Medicine

JF - Annals of Internal Medicine

SN - 0003-4819

IS - 11

ER -