Adiposity-independent sympathetic activity in black men

Aamer Abbas, Lidia S. Szczepaniak, Meryem Tuncel, Jonathan M. McGavock, Beverley Huet, Paul J. Fadel, Zhongyun Wang, Debbie Arbique, Ronald Victor, Wanpen Vongpatanasin

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Obsity is thought to lead to sympathetic overactivity as a compensatory adjustment to weight gain. However, most of the experimental support for the hypothesis has been derived from white cohorts. Our previous study in blacks indicated that sympathetic nerve activity (SNA) is closely correlated with body mass index only in women, whereas, in black men, SNA is elevated and dissociated from adiposity (Abate et al., Hypertension 38: 379-383, 2001). To further determine whether total and regional adiposity are determinants of SNA in blacks, we performed a prospective weight loss study in 12 normotensive obese black men and 9 obese black women. SNA, body mass index, and abdominal fat mass were measured before and 16 wk after hypocaloric diet. The major new findings are that, in obese black men, the dietary-induced weight loss of 11.3 ± 0.8 kg resulted in reduction in plasma leptin, insulin, and visceral abdominal fat but had no effect on SNA (from baseline of 26 ± 4 to 28 ± 3 bursts/min, P = not significant). In contrast, in black women, weight loss of 8.0 ± 0.9 kg caused similar reductions in plasma leptin, insulin, and visceral abdominal fat and led to a reduction in SNA by 40% (from baseline of 22 ± 2 to 13 ± 3 bursts/min, P < 0.05). In conclusion, these new data from this prospective study provide strong support for a major adiposity-independent sympathetic activity in black men and adiposity-related sympathetic activity in black women.

Original languageEnglish (US)
Pages (from-to)1613-1618
Number of pages6
JournalJournal of Applied Physiology
Volume108
Issue number6
DOIs
StatePublished - Jun 2010

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Adiposity
Weight Loss
Intra-Abdominal Fat
Leptin
Body Mass Index
Insulin
Abdominal Fat
Weight Gain
Prospective Studies
Diet
Hypertension

Keywords

  • Baroreceptor
  • Blacks
  • Insulin
  • Obesity
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Abbas, A., Szczepaniak, L. S., Tuncel, M., McGavock, J. M., Huet, B., Fadel, P. J., ... Vongpatanasin, W. (2010). Adiposity-independent sympathetic activity in black men. Journal of Applied Physiology, 108(6), 1613-1618. https://doi.org/10.1152/japplphysiol.00058.2010

Adiposity-independent sympathetic activity in black men. / Abbas, Aamer; Szczepaniak, Lidia S.; Tuncel, Meryem; McGavock, Jonathan M.; Huet, Beverley; Fadel, Paul J.; Wang, Zhongyun; Arbique, Debbie; Victor, Ronald; Vongpatanasin, Wanpen.

In: Journal of Applied Physiology, Vol. 108, No. 6, 06.2010, p. 1613-1618.

Research output: Contribution to journalArticle

Abbas, A, Szczepaniak, LS, Tuncel, M, McGavock, JM, Huet, B, Fadel, PJ, Wang, Z, Arbique, D, Victor, R & Vongpatanasin, W 2010, 'Adiposity-independent sympathetic activity in black men', Journal of Applied Physiology, vol. 108, no. 6, pp. 1613-1618. https://doi.org/10.1152/japplphysiol.00058.2010
Abbas A, Szczepaniak LS, Tuncel M, McGavock JM, Huet B, Fadel PJ et al. Adiposity-independent sympathetic activity in black men. Journal of Applied Physiology. 2010 Jun;108(6):1613-1618. https://doi.org/10.1152/japplphysiol.00058.2010
Abbas, Aamer ; Szczepaniak, Lidia S. ; Tuncel, Meryem ; McGavock, Jonathan M. ; Huet, Beverley ; Fadel, Paul J. ; Wang, Zhongyun ; Arbique, Debbie ; Victor, Ronald ; Vongpatanasin, Wanpen. / Adiposity-independent sympathetic activity in black men. In: Journal of Applied Physiology. 2010 ; Vol. 108, No. 6. pp. 1613-1618.
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AB - Obsity is thought to lead to sympathetic overactivity as a compensatory adjustment to weight gain. However, most of the experimental support for the hypothesis has been derived from white cohorts. Our previous study in blacks indicated that sympathetic nerve activity (SNA) is closely correlated with body mass index only in women, whereas, in black men, SNA is elevated and dissociated from adiposity (Abate et al., Hypertension 38: 379-383, 2001). To further determine whether total and regional adiposity are determinants of SNA in blacks, we performed a prospective weight loss study in 12 normotensive obese black men and 9 obese black women. SNA, body mass index, and abdominal fat mass were measured before and 16 wk after hypocaloric diet. The major new findings are that, in obese black men, the dietary-induced weight loss of 11.3 ± 0.8 kg resulted in reduction in plasma leptin, insulin, and visceral abdominal fat but had no effect on SNA (from baseline of 26 ± 4 to 28 ± 3 bursts/min, P = not significant). In contrast, in black women, weight loss of 8.0 ± 0.9 kg caused similar reductions in plasma leptin, insulin, and visceral abdominal fat and led to a reduction in SNA by 40% (from baseline of 22 ± 2 to 13 ± 3 bursts/min, P < 0.05). In conclusion, these new data from this prospective study provide strong support for a major adiposity-independent sympathetic activity in black men and adiposity-related sympathetic activity in black women.

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